BIOPEP-UWM: Report

ID 3528
Name ACE inhibitor
sequence
LVR

Function:
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: XM02-001)
 
Number of residues
3
Activity code
ah
Activity :
ACE inhibitor
Chemical mass 386.4883 Monoisotopic mass 386.2634
EC50 :
14.00 µM



Bibliographic data:
Authors
Maruyama S., Miyoshi S., Tanaka H.
Title
Angiotensin I-converting enzyme inhibitors derived from Ficus carica. Agric. Biol. Chem., 53(10), 2763-2767 (1989)
Year Source
1989 Journal



Additional information:
BIOPEP-UWM database of bioactive peptides

SMILES: [H][C@](N)(CC(C)C)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CCCNC(N)=N)C(O)=O

InChI=1S/C17H34N6O4/c1-9(2)8-11(18)14(24)23-13(10(3)4)15(25)22-12(16(26)27)6-5-7-21-17(19)20/h9-13H,5-8,18H2,1-4H3,(H,22,25)(H,23,24)(H,26,27)(H4,19,20,21)/t11-,12-,13-/m0/s1

InChIKey=FBNPMTNBFFAMMH-AVGNSLFASA-N



Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/); ID: XM02-001

Peptide found also in amaranth protein hydrolysate.

Barba de la Rosa A. P., Barba Montoya A., Martínez-Cuevas P., Hernández-Ledesma B., León-Galván M. F., De León-Rodríguez A., González C., 2010, Tryptic amaranth glutelin digests induce endothelial nitric oxide production through inhibition of ACE: antihypertensive role of amaranth peptides. Nitric Oxide, 23, 106-111



Database reference: