BIOPEP-UWM: Report

ID 3532
Name ACE inhibitor
sequence
GY
Function:
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
 
Number of residues
2
Activity code
ah
Activity :
ACE inhibitor
Chemical mass 238.2393 Monoisotopic mass 238.0950
EC50 :
210.00 µM


Bibliographic data:
Authors
Cheung H.-S., Wang F.-L., Ondetti M. A., Sabo E. F., Cushman D. W.
Title
Binding of peptide substrates and inhibitors of angiotensin-converting enzyme. J. Biol. Chem., 255, 401-407, 1980
Year Source
1980 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: NCC(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)O

InChI=1S/C11H14N2O4/c12-6-10(15)13-9(11(16)17)5-7-1-3-8(14)4-2-7/h1-4,9,14H,5-6,12H2,(H,13,15)(H,16,17)/t9-/m0/s1

InChIKey=XBGGUPMXALFZOT-VIFPVBQESA-N


Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/); ID: M02-001

Another value of peptide IC50 = 259 uM

Saito Y., Wanezaki K., Kawato A., Imayasu S., 1994, Antihypertensive effects of peptide in sake and its by-products on spontaneously antihypertensive rats. Biosci. Biotech. Biochem., 58, 812-816


Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP-UWM database of bioactive peptides (ID 8788)
Inhibitor of tripeptidyl-peptidase II (EC 3.4.14.10) (MEROPS ID: S08.090) according to the BRENDA database
Inhibitor of carboxypeptidase A (EC 3.4.17.1) (MEROPS ID: M14.001) according to the BRENDA database


Bitter peptide according to the BIOPEP-UWM database of sensory peptides and amino acids (ID 32)


Isolated from silk fibroin hydrolysate.
Zhou F., Xue Z., Wang J., 2010, Antihypertensive effects of silk fibroin hydrolysate by alcalase and purification of an ACE inhibitory dipeptide. J. Agric. Food Chem., 58, 6735-6740

Found in amaranth (Amarantus hypochondriacus) protein hydrolysate:

Barba de la Rosa A. P., Barba Montoya A., Martínez-Cuevas P., Hernández-Ledesma B., León-Galván M. F., De León-Rodríguez A., González C., 2010, Tryptic amaranth glutelin digests induce endothelial nitric oxide production through inhibition of ACE: antihypertensive role of amaranth peptides. Nitric Oxide, 23, 106-111


Database reference:
AHTPDB: ID 1110; 1140; 1270; 1372; 1380; 1400; 1419; 1809; 1891; 2653; 2746; 2790; 2934; 2980; 3101; 3301; 3496; 3843; 3938; 4075; 4230; 4250; 4251; 4440; 4497; 4682; 5153; 5430; 5591; 5740; 6210; 6450

BindingDB: ID 50188508

BIOPEP-UWM database of bioactive peptides: ID 8788

BIOPEP-UWM database of sensory peptides and amino acids: ID 32

BRENDA: Ligand Gly-Tyr

CAS: Registry No 658-79-7

ChEBI: ID 73517

ChEMBL: ID CHEMBL53400

ChemSpider ID: 83798

DFBP: ID DFBPACEI1231, DFBPANHY0659, DFBPANHY0951, DFBPANHY0649, DFBPMUFU0266

DrugBank: ID DB15991

EChA: 211-525-1

EPA CompTox: ID DTXSID701316223

EROP-Moscow: ID E09245

FDA SRS: ID A226496H4O

FooDB: ID FDB111885

GSRS: ID f8be4252-ac07-465c-887e-ec15d77e7d6a

HMDB: ID HMDB0028853

J-GLOBAL: ID 200907090094114372

MeSH: Terms Gly-Tyr; glycyl-L-tyrosine

Metabolights: ID MTBLC73517

MMDB: ID 3008.2

Metabolomics Workbench: ID 78814

NIAID: ID 192299, 192300, 192302, 192309

Nikkaji: ID J149.623I

NMRShiftDB: ID 60023651

PLantPepDB: ID PPepDB_2967

ProbesDrugs: ID PD143805

PubChem: CID 92829

SATPdb: ID satpdb13322

SureChEMBL: ID SCHEMBL479126

UNII: ID A226496H4O

VMH: ID GLYTYR

Wikidata: Q27140599

ZINC: ID ZINC01730678