BIOPEP-UWM: Report

ID 3541
Name ACE inhibitor
sequence
LSP

Function:
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: XM02-001)
 
Number of residues
3
Activity code
ah
Activity :
ACE inhibitor
Chemical mass 315.3644 Monoisotopic mass 315.1788
EC50 :
1.70 µM



Bibliographic data:
Authors
Miyoshi S., Kaneko T., Ishikawa H., Tanaka H., Maruyama S.
Title
Production of bioactive peptides from corn endosperm proteins by some proteases. Ann. N. Y. Acad. Sci., 750, 429-431 (1995)
Year Source
1995 Journal



Additional information:
BIOPEP-UWM database of bioactive peptides

SMILES: [H][C@](N)(CC(C)C)C(=O)N[C@@]([H])(CO)C(=O)N1CCC[C@@]1([H])C(O)=O

InChI=1S/C14H25N3O5/c1-8(2)6-9(15)12(19)16-10(7-18)13(20)17-5-3-4-11(17)14(21)22/h8-11,18H,3-7,15H2,1-2H3,(H,16,19)(H,21,22)/t9-,10-,11-/m0/s1

InChIKey=SBANPBVRHYIMRR-DCAQKATOSA-N



Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/); ID: XM02-001

Peptide found also in amaranth protein hydrolysate.

Barba de la Rosa A. P., Barba Montoya A., Martínez-Cuevas P., Hernández-Ledesma B., León-Galván M. F., De León-Rodríguez A., González C., 2010, Tryptic amaranth glutelin digests induce endothelial nitric oxide production through inhibition of ACE: antihypertensive role of amaranth peptides. Nitric Oxide, 23, 106-111



Database reference: