BIOPEP-UWM: Report

ID 3543
Name ACE inhibitor
sequence
LRP
Function:
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
 
Number of residues
3
Activity code
ah
Activity :
ACE inhibitor
Chemical mass 384.4725 Monoisotopic mass 384.2478
EC50 :
1.00 µM


Bibliographic data:
Authors
Miyoshi S., Kaneko T., Ishikawa H., Tanaka H., Maruyama S.
Title
Production of bioactive peptides from corn endosperm by some proteases. Ann. N. Y. Acad. Sci., 750, 429-431, 1995
Year Source
1995 Journal


Additional information:

BIOPEP-UWM database of bioactive peptides


SMILES: N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@@H]1C(=O)O

InChI=1S/C17H32N6O4/c1-10(2)9-11(18)14(24)22-12(5-3-7-21-17(19)20)15(25)23-8-4-6-13(23)16(26)27/h10-13H,3-9,18H2,1-2H3,(H,22,24)(H,26,27)(H4,19,20,21)/t11-,12-,13-/m0/s1

InChIKey=IBMVEYRWAWIOTN-AVGNSLFASA-N


Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/); ID: M02-001

Peptide IC50(EC50) ranges from 0,29 to 1 uM.

Loponen J., 2004, Angiotensin converting enzyme inhibitory peptides in Finnish cereals: a database survey. Agric. Food Sci., 13, 39-45

Peptide found also in amaranth protein hydrolysate.

Barba de la Rosa A. P., Barba Montoya A., Martínez-Cuevas P., Hernández-Ledesma B., León-Galván M. F., De León-Rodríguez A., González C., 2010, Tryptic amaranth glutelin digests induce endothelial nitric oxide production through inhibition of ACE: antihypertensive role of amaranth peptides. Nitric Oxide, 23, 106-111


Bitter peptide according to the BIOPEP database of sensory peptides and amino acids

Predicted ligand of SARS-CoV-2 parent protease (EC 3.4.22.69) (MEROPS ID: C30.007) (PDB ID: 6LU7) according to the BIOPEP-UWM Virtual database (ID 46)


Database reference:
AHTPDB: ID 1168; 1280; 1285; 1635; 1871; 1876; 1932; 1963; 2102; 2565; 2570; 2663; 2732; 2862; 3518; 4801; 5094; 5236; 5608; 5669; 5800; 6280; 6460

BindingDB: ID 50169168

BioPepDB: ID biopep00884

BIOPEP-UWM Virtual database: ID 46

BRENDA: Ligand Leu-Arg-Pro

ChEMBL: ID CHEMBL188695

ChemSpider: ID 8105603

EROP-Moscow: ID E09040

FeptideDB: ID 3543

J-GLOBAL: ID 200907045119827381

MBPDB: Peptide LRP

Nikkaji: ID J408.834D

PubChem: CID 9929972

SATPdb: ID satpdb28676

ZINC: ID ZINC04899610