BIOPEP-UWM: Report

ID 3547
Name ACE inhibitor
sequence
IRA

Function:
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: XM02-001)
 
Number of residues
3
Activity code
ah
Activity :
ACE inhibitor
Chemical mass 358.4353 Monoisotopic mass 358.2322
EC50 :
6.40 µM



Bibliographic data:
Authors
Miyoshi S., Ishikawa H., Kaneko T., Fukui F., Tanaka H.
Title
Structure and activity of angiotensin-converting enzyme inhibitors in alpha-zein hydrolysate. Agric. Biol. Chem., 55(5), 1313-1318 (1991)
Year Source
1991 Journal



Additional information:
BIOPEP-UWM database of bioactive peptides

SMILES: [H][C@@](C)(NC(=O)[C@]([H])(CCCNC(N)=N)NC(=O)[C@@]([H])(N)[C@@]([H])(C)CC)C(O)=O

InChI=1S/C15H30N6O4/c1-4-8(2)11(16)13(23)21-10(6-5-7-19-15(17)18)12(22)20-9(3)14(24)25/h8-11H,4-7,16H2,1-3H3,(H,20,22)(H,21,23)(H,24,25)(H4,17,18,19)/t8-,9-,10-,11-/m0/s1

InChIKey=TZCGZYWNIDZZMR-NAKRPEOUSA-N



Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/); ID: XM02-001

Peptide found also in amaranth protein hydrolysate.

Barba de la Rosa A. P., Barba Montoya A., Martínez-Cuevas P., Hernández-Ledesma B., León-Galván M. F., De León-Rodríguez A., González C., 2010, Tryptic amaranth glutelin digests induce endothelial nitric oxide production through inhibition of ACE: antihypertensive role of amaranth peptides. Nitric Oxide, 23, 106-111



Database reference: