BIOPEP-UWM: Report

ID 3550
Name ACE inhibitor (from bovine beta-Lg)
sequence
YL
Function:
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
 
Number of residues
2
Activity code
ah
Activity :
ACE inhibitor
Chemical mass 294.3453 Monoisotopic mass 294.1574
EC50 :
122.00 µM


Bibliographic data:
Authors
Mullally M. M., Meisel H., FitzGerald R. J.
Title
Synthetic peptides corresponding to alpha-lactalbumin and beta-lactoglobulin sequences with angiotensin-I-converting enzyme inhibitory activity. Biol. Chem. Hoppe-Seyler 377, 259-260, 1996
Year Source
1996 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(CC(C)C)C(=O)O

InChI=1S/C15H22N2O4/c1-9(2)7-13(15(20)21)17-14(19)12(16)8-10-3-5-11(18)6-4-10/h3-6,9,12-13,18H,7-8,16H2,1-2H3,(H,17,19)(H,20,21)/t12-,13-/m0/s1

InChIKey=AUEJLPRZGVVDNU-STQMWFEESA-N

Peptide known as alpha/beta-lactokinin [alphas1-CN (91-92), beta-Lg (102-103)]

Peptide found also in amaranth protein hydrolysate. Barba de la Rosa A. P., Barba Montoya A., Martínez-Cuevas P., Hernández-Ledesma B., León-Galván M. F., De León-Rodríguez A., González C., 2010, Tryptic amaranth glutelin digests induce endothelial nitric oxide production through inhibition of ACE: antihypertensive role of amaranth peptides. Nitric Oxide, 23, 106-111

Inhibitor of Dipeptidyl peptidase IV (DPP IV) (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP-UWM database of bioactive peptides (ID: 8940)
Neuropeptide according to the BIOPEP-UWM database of bioactive peptides (ID: 8310)
Inhibitor of Dipeptidyl peptidase III (DPP-III) (EC 3.4.14.4) (MEROPS ID: M49.003) according to the BIOPEP-UWM database of bioactive peptides (ID:9482)
Bitter peptide according to the BIOPEP-UWM database of sensory peptides and amino acids (ID: 484); the ChEMBL database (ID: CHEMBL847173)


Information concerning Dipeptidyl peptidase-III (DPP-III) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/); ID: M49.001)


Database reference:
ACToR: ID 17355-10-1

AHTPDB: ID 1097; 1211; 1316; 1362; 1389; 1409; 2993; 3168; 3172; 3550; 3883; 4054; 4733; 5184; 5637; 5843; 6465

BioPepDB: ID biopep01579

BIOPEP-UWM database of bioactive peptides: ID 8310; 8940; 9482

BIOPEP-UWM database of sensory peptides and amino acids: ID 484

BRENDA: Ligand Tyr-Leu

CHEBI: ID 75003

ChEMBL: ID CHEMBL55259

ChemIDplus: ID 17355-10-1

ChemSpider: ID 78540

CTD: ID 17355-10-1

eMolecules: ID 6878892

J-Global: ID 200907095743204000

Metabolights: ID MTBLC75003

MolPort: ID MolPort-012-238-272

Nikkaji: ID J366.109A

PubChem: CID 87071

SATPdb: ID satpdb21280

SureChEMBL: ID SCHEMBL9822809

ZINC: ID ZINC2384781