BIOPEP-UWM: Report

ID 3551
Name ACE inhibitor
sequence
LF
Function:
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
 
Number of residues
2
Activity code
ah
Activity :
ACE inhibitor
Chemical mass 278.3459 Monoisotopic mass 278.1625
IC50 :
349.00 µM


Bibliographic data:
Authors
Meisel H.
Title
Overview on milk protein-derived peptides. Int. Dairy J., 8, 363-373 (1998)
Year Source
1998 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: N[C@@]([H])(CC(C)C)C(=O)N[C@@H](CC1=CC=C(C=C1))C(=O)O

InChI=1S/C15H22N2O3/c1-10(2)8-12(16)14(18)17-13(15(19)20)9-11-6-4-3-5-7-11/h3-7,10,12-13H,8-9,16H2,1-2H3,(H,17,18)(H,19,20)/t12-,13-/m0/s1

InChIKey=KFKWRHQBZQICHA-STQMWFEESA-N


Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/); ID: M02-001

Peptide known as alpha/beta-lactokinin [alpha-La (52-53); beta-Lg (104-105)]

Another value of peptide EC50 (IC 50) = 382.3 um

Ono S., Hosokawa M., Miyashita K., Takahashi K., 2006, Inhibiton properties of dipeptides from salmon muscle hydrolysate on angiotensin I-converting enzyme. Int. J. Food Sci. Technol., 41, 383-387

Found in salmon protein hydrolysate.

Ono S., Hosokawa M., Miyashita K., Takahashi K., 2006, Inhibiton properties of dipeptides from salmon muscle hydrolysate on angiotensin I-converting enzyme. Int. J. Food Sci. Technol., 41, 383-387

Found in amaranth proteins:

Barba de la Rosa A. P., Barba Montoya A., Martínez-Cuevas P., Hernández-Ledesma B., León-Galván M. F., De León-Rodríguez A., González C., 2010, Tryptic amaranth glutelin digests induce endothelial nitric oxide production through inhibition of ACE: antihypertensive role of amaranth peptides. Nitric Oxide, 23, 106-111


Inhibitor of Carboxypeptidase C (EC 3.4.16.5) (MEROPS ID S10.004) according to the BRENDA database
Inhibitor of Pseudolysin (EC 3.4.24.26) (MEROPS ID M04.005) according to the BIOPEP-UWM database of bioactive peptides (ID 8313); the BRENDA database

Bitter peptide according to BIOPEP database of sensory peptides and amino acids (ID 52); ChEMBL database; EROP-Moscow database; PubChem database


Database reference:
AHTPDB: ID 1161; 1330; 1388; 1415; 1432; 1675; 2687; 3165; 3209; 3302; 3514; 3600; 3854; 3976; 4086; 4473; 5454; 5602; 5711; 5777; 6466

BIOPEP-UWM database of bioactive peptides: ID 8313

BIOPEP-UWM database of sensory peptides and amino acids: ID 52

BRENDA: Ligand Leu-Phe

CAS: Registry No 3063-05-6

CCDC: ID COCGOQ

ChEBI: ID 73585

ChEMBL: ID CHEMBL54936

ChemSpider: ID 5360450

COCONUT: ID CNP0118564.1

eMolecules: ID 8294077

EPA CompTox: ID DTXSID501036415

EROP-Moscow: ID E01831

FooDB: ID FDB111642

HMDB: ID HMDB0013243

J-GLOBAL: ID 200907004967555318

MetaboLights: ID MTBLC73585

Metabolomics Workbench: ID ME015586

Nikkaji: ID J80.629C

NMRShiftDB: ID 60023474

PlantPepDB: ID PPepDB_3721

Probes And Drugs: ID PD101959

PubChem: ID 6992310

SATPdb: ID satpdb28695

SureChEMBL: ID SCHEMBL1864709

Wikidata: ID Q27141902

ZINC: ID ZINC000001569745