BIOPEP-UWM: Report

ID 3551
Name ACE inhibitor (from bovine beta-Lg)
sequence
LF
Function:
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: XM02-001)
 
Number of residues
2
Activity code
ah
Activity :
ACE inhibitor
Chemical mass 278.3459 Monoisotopic mass 278.1625
EC50 :
349.00 µM


Bibliographic data:
Authors
Meisel H.
Title
Overview on milk protein-derived peptides.Int.Dairy J.,8,363-373(1998)
Year Source
1998 Journal


Additional information:
BIOPEP database of bioactive peptides


SMILES: N[C@H](C(=O)N[C@H](C(=O)O)Cc1ccccc1)CC(C)C

InChI=1S/C15H22N2O3/c1-10(2)8-12(16)14(18)17-13(15(19)20)9-11-6-4-3-5-7-11/h3-7,10,12-13H,8-9,16H2,1-2H3,(H,17,18)(H,19,20)/t12-,13-/m0/s1

InChIKey: KFKWRHQBZQICHA-STQMWFEESA-N


Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/); ID: XM02-001

Peptide known as alpha/beta-lactokinin [alpha-La (52-53); beta-Lg (104-105)]

Another value of peptide EC50 (IC 50) = 382.3 um

Ono S., Hosokawa M., Miyashita K., Takahashi K., 2006, Inhibiton properties of dipeptides from salmon muscle hydrolysate on angiotensin I-converting enzyme. Int. J. Food Sci. Technol., 41, 383-387

Found in salmon protein hydrolysate.

Ono S., Hosokawa M., Miyashita K., Takahashi K., 2006, Inhibiton properties of dipeptides from salmon muscle hydrolysate on angiotensin I-converting enzyme. Int. J. Food Sci. Technol., 41, 383-387

Found in amaranth proteins:

Barba de la Rosa A. P., Barba Montoya A., Martínez-Cuevas P., Hernández-Ledesma B., León-Galván M. F., De León-Rodríguez A., González C., 2010, Tryptic amaranth glutelin digests induce endothelial nitric oxide production through inhibition of ACE: antihypertensive role of amaranth peptides. Nitric Oxide, 23, 106-111


Inhibitor of Carboxypeptidase C (EC 3.4.16.5) (MEROPS ID S10.004) according to BRENDA database
Inhibitor of Pseudolysin (EC 3.4.24.26) (MEROPS ID M04.005) according to BRENDA database

Bitter peptide according to BIOPEP database of sensory peptides and amino acids; ChEMBL database; EROP-Moscow database; PubChem database


Database reference:
AHTPDB: ID 1161; 1330; 1388; 1415; 1432; 1675; 2687; 3165; 3209; 3302; 3514; 3600; 3854; 3976; 4086; 4473; 5454; 5602; 5711; 5777; 6466

BIOPEP database of bioactive peptides: ID 3551

BRENDA: Ligand Leu-Phe

ChEBI: ID 73585

ChEMBL: ID CHEMBL54936

ChemSpider: ID 5360450

EROP-Moscow: ID E01831

Metabolomics Workbench: ID ME015586

PubChem: ID 6992310

SATPdb: ID satpdb28695

ZINC: ID ZINC01569745