BIOPEP-UWM: Report
| ID | 3553 |
| Name | ACE inhibitor |
| sequence |
| Function: | |||
| Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001) | |||
| Number of residues | 2 |
Activity code | ah |
| Activity : | ACE inhibitor |
|||
| Chemical mass | 238.2393 | Monoisotopic mass | 238.0950 | |
| EC50 : | 1523.00 µM |
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| Bibliographic data: | |
| Authors | |
| Mullally M. M., Meisel H., FitzGerald R. J. | |
| Title | |
| Synthetic peptides corresponding to alpha-lactalbumin and beta-lactoglobulin sequences with angiotensin-I-converting enzyme inhibitory activity. Biol. Chem. Hoppe-Seyler, 377, 259-261, 1996 | |
| Year | Source |
| 1996 | Journal |
| Additional information: |
| BIOPEP-UWM database of bioactive peptides SMILES: c1cc(ccc1C[C@@H](C(=O)NCC(=O)O)N)O InChI=1S/C11H14N2O4/c12-9(11(17)13-6-10(15)16)5-7-1-3-8(14)4-2-7/h1-4,9,14H,5-6,12H2,(H,13,17)(H,15,16)/t9-/m0/s1 InChIKey: HPYDSVWYXXKHRD-VIFPVBQESA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/); ID: XM02-001 Peptide known as alpha-lactokinin [alpha-La (18-19;50-51), kappa-CN (38-39)]. Another value of peptide IC50(EC50) = 2000 uM Cushman D. W., 1981. Angiotensin converting enzyme inhibitors: Evolution of a new class of antihypertensive drugs (page 19). in: Horovitz Z. P. (Ed.)(1981), Mechanisms of action and clinical implications, Urban & Schwarzenberg. Peptide found in cod protein hydrolysates: Geirsdóttir M., 2009, Isolation, purification and investigation of peptides from fish proteins with blood pressure decreasing properties. Report from the project funded by the AVS research fund under the Ministry of Fisheries in Iceland (project no. R-047-07). Matís Report 36-09, Matís, Reykjavik, Iceland, http://www.avs.is/media/avs/36-09_skyrsla_einangrun_peptida.pdf Peptide found in amaranth protein hydrolysate. Barba de la Rosa A. P., Barba Montoya A., Martínez-Cuevas P., Hernández-Ledesma B., León-Galván M. F., De León-Rodríguez A., González C., 2010, Tryptic amaranth glutelin digests induce endothelial nitric oxide production through inhibition of ACE: antihypertensive role of amaranth peptides. Nitric Oxide, 23, 106-111 Immunomodulating peptide according to the BIOPEP-UWM database of bioactive peptides (ID 2882) Inhibitor of nitrogen uptake in yeasts according to the ChEMBL database Inhibitor of Dipeptidyl peptidase III (EC 3.4.14.4) (MEROPS ID: M49.001) according to the BIOPEP-UWM database of bioactive peptides (ID 9508); the BRENDA database Inhibitor of Dipeptidyl peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP-UWM database database of bioactive peptides (ID 8936) Inhibitor of Tubulin-tyrosine ligase (EC 6.3.2.25) according to the BRENDA database Bitter peptide according to the BIOPEP-UWM database of sensory peptides and amino acids |
| Database reference: |
| AHTPDB: ID 1206; 1327; 1351; 1387; 1480; 2998; 3210; 3303; 3548; 3598; 3803; 4053; 4423; 4509; 4656; 5428; 5635; 6467 BindingDB: ID 50188519 BioPepDB: ID biopep01556 BIOPEP-UWM database of bioactive peptides: ID 2882; 8936; 9508 BIOPEP-UWM database of sensory peptides and amino acids: ID 31 BRENDA: Ligand Tyr-Gly ChEBI: ID 74990 ChEMBL: ID CHEMBL89956 ChemSpider: ID 5384746 EROP-Moscow: ID E09271 HMDB: ID HMDB29105 J-GLOBAL: ID 200907017245435665 Metabolights: ID MTBLC74990 Nikkaji: ID J258.522G PubChem: ID 7021853 SATPdb: ID satpdb13810 SureChEMBL: ID SCHEMBL4407092 ZINC: ID ZINC000002575475 |