BIOPEP-UWM: Report

ID 3556
Name ACE inhibitor
sequence
FY
Function:
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
 
Number of residues
2
Activity code
ah
Activity :
ACE inhibitor
Chemical mass 328.3616 Monoisotopic mass 328.1418
EC50 :
25.00 µM


Bibliographic data:
Authors
Yano S., Suzuki K., Funatsu G.
Title
Isolation from alpha-zein of thermolysin peptides with angiotensin I-converting enzyme inhibitory activity. Biosci. Biotech. Biochem. 60, 661-663 (1996)
Year Source
1996 Journal


Additional information:
Additional information:

BIOPEP database of bioactive peptides


SMILES: N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O

InChI: InChI=1S/C18H20N2O4/c19-15(10-12-4-2-1-3-5-12)17(22)20-16(18(23)24)11-13-6-8-14(21)9-7-13/h1-9,15-16,21H,10-11,19H2,(H,20,22)(H,23,24)/t15-,16-/m0/s1

InChIKey: FSXRLASFHBWESK-HOTGVXAUSA-N



Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/); ID: M02-001

Another value of peptide IC50(EC50) = 3.7

Loponen J., 2004, Angiotensin converting enzyme inhibitory peptides in Finnish cereals: a database survey. Agric. Food Sci., 13, 39-45

Found in amaranth (Amarantus hypochondriacus) protein hydrolysate:

Barba de la Rosa A. P., Barba Montoya A., Martínez-Cuevas P., Hernández-Ledesma B., León-Galván M. F., De León-Rodríguez A., González C., 2010, Tryptic amaranth glutelin digests induce endothelial nitric oxide production through inhibition of ACE: antihypertensive role of amaranth peptides. Nitric Oxide, 23, 106-111


Bitter peptide according to the BIOPEP database of sensory peptides and amino acids (ID 478); the ChEMBL database (ID CHEMBL54572); the PubChem database (ID 515709)


Database reference:
AHTPDB: ID 1136; 1413; 1442; 1446; 1457; 1472; 1810; 1817; 1857; 2654; 2672; 2685; 2775; 2883; 3880; 3913; 4254; 4258; 4731; 4950; 5148; 5587; 5741; 5774; 5808; 6260; 6270; 6469; 6876

BIOPEP database of sensory peptides and amino acids: ID 478

BRENDA: Ligand Phe-Tyr

ChEBI: ID 73637

ChEMBL: ID CHEMBL54572

ChemSpider: ID 449878

EPA DSSTox: ID DTXCID40284746

EROP-Moscow: ID E00283

NIAID: ID 192291

ParaPep: ID 1532; 1560

PubChem: CID 515709

SATPdb: ID satpdb15002

ZINC: ID ZINC02384778