BIOPEP-UWM: Report

ID 3557
Name ACE inhibitor
sequence
FNQ

Function:
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: XM02-001)
 
Number of residues
3
Activity code
ah
Activity :
ACE inhibitor
Chemical mass 407.4200 Monoisotopic mass 407.1799
EC50 :
335.00 µM



Bibliographic data:
Authors
Yano S., Suzuki K., Funatsu G.
Title
Isolation from alpha-zein of thermolysin peptides with angiotensin I-converting enzyme inhibitory activity. Biosci. Biotech. Biochem., 60(4), 661-663 (1996)
Year Source
1996 Journal



Additional information:
BIOPEP-UWM database of bioactive peptides

SMILES: [H][C@](N)(Cc1ccccc1)C(=O)N[C@@]([H])(CC(N)=O)C(=O)N[C@@]([H])(CCC(N)=O)C(O)=O

InChI=1S/C18H25N5O6/c19-11(8-10-4-2-1-3-5-10)16(26)23-13(9-15(21)25)17(27)22-12(18(28)29)6-7-14(20)24/h1-5,11-13H,6-9,19H2,(H2,20,24)(H2,21,25)(H,22,27)(H,23,26)(H,28,29)/t11-,12-,13-/m0/s1

InChIKey=MRNRMSDVVSKPGM-AVGNSLFASA-N


Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/); ID: XM02-00.

Peptide found also in amaranth protein hydrolysate.

Barba de la Rosa A. P., Barba Montoya A., Martínez-Cuevas P., Hernández-Ledesma B., León-Galván M. F., De León-Rodríguez A., González C., 2010, Tryptic amaranth glutelin digests induce endothelial nitric oxide production through inhibition of ACE: antihypertensive role of amaranth peptides. Nitric Oxide, 23, 106-111



Database reference: