BIOPEP-UWM: Report

ID 3563
Name ACE inhibitor
sequence
AY
Function:
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: XM02-001)
 
Number of residues
2
Activity code
ah
Activity :
ACE inhibitor
Chemical mass 252.2658 Monoisotopic mass 252.1106
EC50 :
19.00 µM


Bibliographic data:
Authors
Yano S., Suzuki K., Funatsu G.
Title
Isolation from alpha-zein of thermolysin peptides with angiotensin I-converting enzyme inhibitory activity. Biosci.Biotech.Biochem.60(4),661-663(1996)
Year Source
1996 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides

SMILES: [H][C@@](C)(N)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(O)=O

InChI=1S/C12H16N2O4/c1-7(13)11(16)14-10(12(17)18)6-8-2-4-9(15)5-3-8/h2-5,7,10,15H,6,13H2,1H3,(H,14,16)(H,17,18)/t7-,10-/m0/s1

InChIKey=ALZVPLKYDKJKQU-XVKPBYJWSA-N



Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/); ID: XM02-001

Another value of peptide IC50(EC50) = 88uM

Cushman D. W., 1981. Angiotensin converting enzyme inhibitors: Evolution of a new class of antihypertensive drugs (page 19). in: Horovitz Z. P. (Ed.)(1981), Mechanisms of action and clinical implications, Urban & Schwarzenberg.

Found in amaranth (Amarantus hypochondriacus) protein hydrolysate:

Barba de la Rosa A. P., Barba Montoya A., Martínez-Cuevas P., Hernández-Ledesma B., León-Galván M. F., De León-Rodríguez A., González C., 2010, Tryptic amaranth glutelin digests induce endothelial nitric oxide production through inhibition of ACE: antihypertensive role of amaranth peptides. Nitric Oxide, 23, 106-111

Found in Okara, by-product obtained during the manufacturing of soymilk and tofu.

Yokomizo A., Takenaka Y., Takenaka T., 2002, Antioxidative activity of peptides prepared from Okara protein. Food Sci. Technol. Res., 8, 357-359

Found in corn milling byproducts.

Lin F., Chen L., Liang R., Zhang Z., Wang J., Cai M., Li Y., 2011, Pilot-scale production of low molecular weight peptides from corn wet milling byproducts and the antihypertensive effects in vivo and in vitro. Food Chem., 124, 801-807


Possesses also antioxidative activity (BIOPEP ID 7866)


Database reference: