BIOPEP-UWM: Report
| ID | 3563 |
| Name | ACE inhibitor |
| sequence |
| Function: | |||
| Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001) | |||
| Number of residues | 2 |
Activity code | ah |
| Activity : | ACE inhibitor |
|||
| Chemical mass | 252.2658 | Monoisotopic mass | 252.1106 | |
| EC50 : | 19.00 µM |
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| Bibliographic data: | |
| Authors | |
| Yano S., Suzuki K., Funatsu G. | |
| Title | |
| Isolation from alpha-zein of thermolysin peptides with angiotensin I-converting enzyme inhibitory activity. Biosci. Biotech. Biochem., 60(4), 661-663 (1996) | |
| Year | Source |
| 1996 | Journal |
| Additional information: |
| BIOPEP-UWM database of bioactive peptides N[C@@]([H])(C)C(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)O InChI=1S/C12H16N2O4/c1-7(13)11(16)14-10(12(17)18)6-8-2-4-9(15)5-3-8/h2-5,7,10,15H,6,13H2,1H3,(H,14,16)(H,17,18)/t7-,10-/m0/s1 InChIKey=ALZVPLKYDKJKQU-XVKPBYJWSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/); ID: M02-001 Another value of peptide IC50(EC50) = 88uM Cushman D. W., 1981. Angiotensin converting enzyme inhibitors: Evolution of a new class of antihypertensive drugs (page 19). in: Horovitz Z. P. (Ed.)(1981), Mechanisms of action and clinical implications, Urban & Schwarzenberg. Found in amaranth (Amarantus hypochondriacus) protein hydrolysate: Barba de la Rosa A. P., Barba Montoya A., Martínez-Cuevas P., Hernández-Ledesma B., León-Galván M. F., De León-Rodríguez A., González C., 2010, Tryptic amaranth glutelin digests induce endothelial nitric oxide production through inhibition of ACE: antihypertensive role of amaranth peptides. Nitric Oxide, 23, 106-111 Found in Okara, by-product obtained during the manufacturing of soymilk and tofu. Yokomizo A., Takenaka Y., Takenaka T., 2002, Antioxidative activity of peptides prepared from Okara protein. Food Sci. Technol. Res., 8, 357-359 Found in corn milling byproducts. Lin F., Chen L., Liang R., Zhang Z., Wang J., Cai M., Li Y., 2011, Pilot-scale production of low molecular weight peptides from corn wet milling byproducts and the antihypertensive effects in vivo and in vitro. Food Chem., 124, 801-807 Antioxidative peptide according to the BIOPEP-UWM database of bioactive peptides (ID 7866) Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP-UWM database of bioactive peptides (ID 8765) Inhibitor of Tubulin-tyrosine ligase (EC 6.3.2.25) according to the BIOPEP-UWM database of bioactive peptides, the BRENDA database |
| Database reference: |
| AHTPDB: ID 1127, 1268, 1365, 1414, 1500, 1877, 1889, 2650, 2686, 2744, 2977, 3004, 3072, 3175, 3211, 3469, 3757, 3787, 3894, 4068, 4444, 4493, 4670, 5138, 5583, 5719, 5782, 6208, 6472 AODB: ID AOPE0711 BindingDB: ID 50188523 BIOPEP-UWM database of bioactive peptide: ID 7866; 8765 BRENDA: Ligand Ala-Tyr CAS: Registry No 3061-88-9 ChEBI: ID 73395 ChEMBL: ID CHEMBL94016 Chemspider: ID 83903 DFBP: ID DFBPACEI0616, DFBPANHY0455, DFBPANHY0656, DFBPANHY0945, DFBPANOX0047, DFBPANOX0775, DFBPMUFU0141 ECHA: ID 221-305-7 EPA CompTox: ID DTXSID00184677 EROP-Moscow: ID E04098 FermFooDB: ID FMDB844, FMDB1996 FooDB: ID FDB111756 HMDB: ID HMDB0028699 J-GLOBAL: ID 200907058047799951 Metabolights: ID MTBLC73395 Metabolomics Workbench: ID 78674 Nikkaji: ID J80.626I NMRShiftDB: ID 60023645 PepLife: ID 1196 PlantPepDB: ID PPepDB_240 PubChem: CID 92946 Sabio-RK: ID 23225, 25527 SATPdb: ID satpdb10146 SureChEMBL: ID SCHEMBL2493049 ZINC: ID ZINC000002390894 |