BIOPEP-UWM: Report

ID 3597
Name ACE inhibitor
sequence
AIP

Function:
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
 
Number of residues
3
Activity code
ah
Activity :
ACE inhibitor
Chemical mass 299.3650 Monoisotopic mass 299.1839
IC50 :
670.00 µM



Bibliographic data:
Authors
Kohmura M., Nio N., Ariyoshi Y.
Title
Inhibition of angiotensin-converting enzyme by synthetic peptide fragments of various beta-caseins. Agric. Biol. Chem. 54 (4), 1101-1102 (1990)
Year Source
1990 Journal



Additional information:
BIOPEP-UWM database of bioactive peptides

SMILES: [H][C@@](C)(N)C(=O)N[C@]([H])(C(=O)N1CCC[C@@]1([H])C(O)=O)[C@@]([H])(C)CC

InChI=1S/C14H25N3O4/c1-4-8(2)11(16-12(18)9(3)15)13(19)17-7-5-6-10(17)14(20)21/h8-11H,4-7,15H2,1-3H3,(H,16,18)(H,20,21)/t8-,9-,10-,11-/m0/s1

InChIKey=OKIKVSXTXVVFDV-NAKRPEOUSA-N


Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/); ID: M02-001

Peptide found also in amaranth protein hydrolysate.

Barba de la Rosa A. P., Barba Montoya A., Martínez-Cuevas P., Hernández-Ledesma B., León-Galván M. F., De León-Rodríguez A., González C., 2010, Tryptic amaranth glutelin digests induce endothelial nitric oxide production through inhibition of ACE: antihypertensive role of amaranth peptides. Nitric Oxide, 23, 106-111



Database reference:
AHTPDB: ID 1121, 2258, 2268, 4752, 5191, 5580, 5862, 6044, 6473

ChemSpider: ID 8055028

EROP-Moscow: ID E14563, E09239

FeptideDB: ID 3597

PubChem: CID 9879351

SATPdb: ID satpdb28416