BIOPEP-UWM: Report

ID 3617
Name Alpha-amylase inhibitor
sequence
RVCRRRSAGFKGLCMSDHNCAQVCLQEGWGGGNCDGVMRQCKCIRQC
Function:
Inhibitor of Alpha-amylase (EC 3.2.1.1)
 
Number of residues
47
Activity code
aami
Activity :
alpha-amylase inhibitor
Chemical mass 5222.0762 Monoisotopic mass 5218.3236
IC50 :
0.00 µM


Bibliographic data:
Authors
Nitti G., Orru S., Bloch C., Morhy L., Marino G., Pucci P.
Title
Amino acid sequence and disulphide-bridge pattern of three gamma-thionins from Sorghum bicolor. Eur. J. Biochem., 228, 250-256, 1995
Year Source
1995 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC2=C[N]([H])C=N2)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CS)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCC(=O)O)C(=O)NCC(=O)N[C@@H](CC3=C[N]([H])C4=CC=CC=C34)C(=O)NCC(=O)NCC(=O)NCC(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)N[C@@H]([C@H](CC)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CS)C(=O)O

InChI=1S/C208H344N76O62S10/c1-17-101(12)162(201(344)264-116(44-32-64-236-208(228)229)173(316)261-120(47-52-145(214)289)178(321)280-142(94-354)202(345)346)284-197(340)141(93-353)274-175(318)111(39-24-26-58-210)257-192(335)136(88-348)273-177(320)119(46-51-144(213)288)260-172(315)113(41-29-61-233-205(222)223)256-179(322)123(56-66-356-16)265-198(341)159(98(6)7)281-155(299)84-244-169(312)131(74-157(302)303)269-195(338)138(90-350)277-186(329)129(72-147(216)291)251-151(295)80-239-149(293)78-238-150(294)79-241-168(311)127(70-105-76-237-109-37-22-21-35-107(105)109)250-154(298)83-243-167(310)117(49-54-156(300)301)259-176(319)118(45-50-143(212)287)262-183(326)125(68-97(4)5)266-196(339)140(92-352)279-200(343)161(100(10)11)283-181(324)121(48-53-146(215)290)252-164(307)103(14)247-191(334)135(87-347)275-187(330)130(73-148(217)292)268-185(328)128(71-106-77-230-95-245-106)267-188(331)132(75-158(304)305)270-190(333)134(86-286)272-180(323)122(55-65-355-15)263-193(336)137(89-349)276-182(325)124(67-96(2)3)248-153(297)82-242-166(309)110(38-23-25-57-209)253-184(327)126(69-104-33-19-18-20-34-104)249-152(296)81-240-163(306)102(13)246-189(332)133(85-285)271-174(317)115(43-31-63-235-207(226)227)255-170(313)112(40-28-60-232-204(220)221)254-171(314)114(42-30-62-234-206(224)225)258-194(337)139(91-351)278-199(342)160(99(8)9)282-165(308)108(211)36-27-59-231-203(218)219/h18-22,33-35,37,76-77,95-103,108,110-142,159-162,237,285-286,347-354H,17,23-32,36,38-75,78-94,209-211H2,1-16H3,(H2,212,287)(H2,213,288)(H2,214,289)(H2,215,290)(H2,216,291)(H2,217,292)(H,230,245)(H,238,294)(H,239,293)(H,240,306)(H,241,311)(H,242,309)(H,243,310)(H,244,312)(H,246,332)(H,247,334)(H,248,297)(H,249,296)(H,250,298)(H,251,295)(H,252,307)(H,253,327)(H,254,314)(H,255,313)(H,256,322)(H,257,335)(H,258,337)(H,259,319)(H,260,315)(H,261,316)(H,262,326)(H,263,336)(H,264,344)(H,265,341)(H,266,339)(H,267,331)(H,268,328)(H,269,338)(H,270,333)(H,271,317)(H,272,323)(H,273,320)(H,274,318)(H,275,330)(H,276,325)(H,277,329)(H,278,342)(H,279,343)(H,280,321)(H,281,299)(H,282,308)(H,283,324)(H,284,340)(H,300,301)(H,302,303)(H,304,305)(H,345,346)(H4,218,219,231)(H4,220,221,232)(H4,222,223,233)(H4,224,225,234)(H4,226,227,235)(H4,228,229,236)/t101-,102-,103-,108-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,159-,160-,161-,162-/m0/s1

InChIKey: YASXGSHLOLOEFV-HZDKOFMJSA-N


Disulfide bonds between the residues 3-47, 14-34, 20-41, 24-43 according to the EROP-Moscow database
________________________________________


Database reference:
EROP-Moscow: ID E03021

UniProtKB: Access. No Q09198