BIOPEP-UWM: Report

ID 3666
Name ACE inhibitor
sequence
YP
Function:
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
 
Number of residues
2
Activity code
ah
Activity :
ACE inhibitor
Chemical mass 278.3030 Monoisotopic mass 278.1262
IC50 :
720.00 µM


Bibliographic data:
Authors
Lantz I., Glamsta E. L., Talback L., Nyberg F.
Title
Hemorfins derived from hemoglobin have an inhibitory action on angiotensin converting enzyme activity. FEBS Lett., 287, 39-41, 1991
Year Source
1991 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: N[C@H](C(=O)N1[C@H](C(=O)O)CCC1)Cc1ccc(cc1)O

InChI=1S/C14H18N2O4/c15-11(8-9-3-5-10(17)6-4-9)13(18)16-7-1-2-12(16)14(19)20/h3-6,11-12,17H,1-2,7-8,15H2,(H,19,20)/t11-,12-/m0/s1

InChIKey: VNYDHJARLHNEGA-RYUDHWBXSA-N


Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/); ID: M02-001

Peptide EC50 value comes from AHTPDB database: http://crdd.osdd.net/raghava/ahtpdb/

Peptide found also in amaranth protein hydrolysate.

Barba de la Rosa A. P., Barba Montoya A., Martínez-Cuevas P., Hernández-Ledesma B., León-Galván M. F., De León-Rodríguez A., González C., 2010, Tryptic amaranth glutelin digests induce endothelial nitric oxide production through inhibition of ACE: antihypertensive role of amaranth peptides. Nitric Oxide, 23, 106-111


Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP-UWM database of bioactive peptides (ID 8521); the BRENDA database
Inhibitor of alpha-glucosidase (EC 3.2.1.20) according to the BIOPEP-UWM database of bioactive peptides (ID 9548)

Bitter peptide according to the BIOPEP-UWM database of sensory peptides and amino acids


Database reference:
AHTPDB: ID 1213; 1344; 1349; 1386; 1673; 1706; 2683; 2981; 2985; 3111; 3405; 3551; 3638; 4055; 4130; 4176; 4951; 5574; 5638; 6474

BindingDB: ID 50348856

BioPepDB: ID biopep01590

BIOPEP-UWM database of bioactive peptides: ID 8521; 9548

BIOPEP-UWM database of sensory peptides and amino acids; ID 71

BRENDA: Ligand Tyr-Pro

ChEBI: ID 141456

ChEMBL: ID CHEMBL1807689

ChemSpider: ID 7971403

EPA DSSTox: ID DTXCID90381673

EROP-Moscow: ID E06297; E09272

J-GLOBAL: ID 200907049822444422

Nikkaji: ID J453.042J

PubChem: CID 9795637

SATPdb: ID satpdb19838

SureChEMBL: ID SCHEMBL5336562

ZINC: ID ZINC04899652