BIOPEP-UWM: Report

ID 3976
Name ACE inhibitor
sequence
LAMA
Function:
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: XM02-001)
 
Number of residues
4
Activity code
ah
Activity :
ACE inhibitor
Chemical mass 404.5246 Monoisotopic mass 404.2086
IC50 :
1062.00 µM


Bibliographic data:
Authors
Pihlanto-Leppälä A., Koskinen P., Piilola K., Tupasela T., Korhonen H.
Title
Angiotensin I-converting enzyme inhibitory properties of whey protein digests: concentration and characterization of active peptides. J. Dairy Res., 67, 53-64, 2000
Year Source
2000 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides

SMILES: [H][C@](N)(CC(C)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCSC)C(=O)N[C@@]([H])(C)C(O)=O

InChI=1S/C17H32N4O5S/c1-9(2)8-12(18)15(23)19-10(3)14(22)21-13(6-7-27-5)16(24)20-11(4)17(25)26/h9-13H,6-8,18H2,1-5H3,(H,19,23)(H,20,24)(H,21,22)(H,25,26)/t10-,11-,12-,13-/m0/s1

InChIKey=NRMOFKYAEXORGF-CYDGBPFRSA-N


Database reference:


Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/); ID: XM02-001

Peptide found also in amaranth protein hydrolysate.

Barba de la Rosa A. P., Barba Montoya A., Martínez-Cuevas P., Hernández-Ledesma B., León-Galván M. F., De León-Rodríguez A., González C., 2010, Tryptic amaranth glutelin digests induce endothelial nitric oxide production through inhibition of ACE: antihypertensive role of amaranth peptides. Nitric Oxide, 23, 106-111