BIOPEP-UWM: Report

ID 3989
Name Human urotensin II
sequence
ETPDCFWKYCV
Function:
 
Number of residues
11
Activity code
orp
Activity :
orphan receptor GPR14 agonist
Chemical mass 1390.5806 Monoisotopic mass 1389.5713
EC50 :
0.00 µM


Bibliographic data:
Authors
Ames R. S. et al.
Title
Human urotensin II is a potent vasoconstrictor and agonist for the orphan receptor GPR14.Nature, 401, 282-286
Year Source
1999 Journal


Additional information:
Active in cyclic form. The disulphide bond occurs between Cys5 and Cys10. Activity measured using human orphan receptor. The EC50 against rat receptor is 0.00072 micromole. The molecular masses are calculated for reduced form.

BIOPEP-UWM database of bioactive peptides

SMILES: [H][C@](N)(CCC(O)=O)C(=O)N[C@]([H])(C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CC(O)=O)C(=O)N[C@@]([H])(CS)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(CS)C(=O)N[C@@]([H])(C(C)C)C(O)=O)[C@@]([H])(C)O

InChI=1S/C64H87N13O18S2/c1-33(2)52(64(94)95)75-61(91)48(32-97)74-57(87)44(27-36-18-20-38(79)21-19-36)69-55(85)42(16-9-10-24-65)68-58(88)45(28-37-30-67-41-15-8-7-14-39(37)41)71-56(86)43(26-35-12-5-4-6-13-35)70-60(90)47(31-96)73-59(89)46(29-51(82)83)72-62(92)49-17-11-25-77(49)63(93)53(34(3)78)76-54(84)40(66)22-23-50(80)81/h4-8,12-15,18-21,30,33-34,40,42-49,52-53,67,78-79,96-97H,9-11,16-17,22-29,31-32,65-66H2,1-3H3,(H,68,88)(H,69,85)(H,70,90)(H,71,86)(H,72,92)(H,73,89)(H,74,87)(H,75,91)(H,76,84)(H,80,81)(H,82,83)(H,94,95)/t34-,40+,42+,43+,44+,45+,46+,47+,48+,49+,52+,53+/m1/s1

InChIKey=OFADXNWQLHHILF-USJMABIRSA-N


Database reference: