BIOPEP-UWM: Report

ID 3990
Name Accutin
sequence
GAQCTAGPCCWPCEGTICRRARGDDLDDYCNGISADCPRNPYY
Function:
 
Number of residues
43
Activity code
at
Activity :
antithrombotic
Chemical mass 4688.1565 Monoisotopic mass 4684.9103
EC50 :
0.00 µM


Bibliographic data:
Authors
Yeh C.-H. et al.
Title
A new short chain RGD-containing disintegrin, accutin inhibits the common pathway of human platelet aggregation. Biochim. Biophys. Acta, 1425, 493-504
Year Source
1995 Journal


Additional information:
Peptide belongs to the disintegrin family. For a review see: Huang T. F., Liu C. Z., The biological activity of disintegrins and their possible applications. J. Toxicol. Toxin Rev., 16, 1997, 135-161. Mechanisms of integrin-mediated adhesion processes have been reviewed in: Giancotti F. G., Ruoslahti E., Signal transduction - integrin signalling. Science, 285, 1999, 1028-1035. Molecular mass calculated for reduced form.

BIOPEP-UWM database of bioactive peptides

SMILES: [H][C@](C)(O)[C@]([H])(NC(=O)CNC(=O)[C@]([H])(CCC(O)=O)NC(=O)[C@]([H])(CS)NC(=O)[C@]1([H])CCCN1C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@]([H])(CS)NC(=O)[C@]([H])(CS)NC(=O)[C@]1([H])CCCN1C(=O)CNC(=O)[C@]([H])(C)NC(=O)[C@@]([H])(NC(=O)[C@]([H])(CS)NC(=O)[C@]([H])(CCC(N)=O)NC(=O)[C@]([H])(C)NC(=O)CN)[C@@]([H])(C)O)C(=O)N[C@]([H])(C(=O)N[C@@]([H])(CS)C(=O)N[C@@]([H])(CCCNC(N)=N)C(=O)N[C@@]([H])(CCCNC(N)=N)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCCNC(N)=N)C(=O)NCC(=O)N[C@@]([H])(CC(O)=O)C(=O)N[C@@]([H])(CC(O)=O)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CC(O)=O)C(=O)N[C@@]([H])(CC(O)=O)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(CS)C(=O)N[C@@]([H])(CC(N)=O)C(=O)NCC(=O)N[C@]([H])(C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CC(O)=O)C(=O)N[C@@]([H])(CS)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CCCNC(N)=N)C(=O)N[C@@]([H])(CC(N)=O)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(O)=O)[C@@]([H])(C)CC)[C@@]([H])(C)CC

InChI=1S/C192H289N59O65S7/c1-13-86(5)147(181(308)236-121(77-252)170(297)216-91(10)154(281)225-114(67-143(270)271)169(296)243-128(84-323)187(314)251-58-24-32-130(251)178(305)224-106(30-20-54-208-192(203)204)160(287)234-119(65-135(196)260)186(313)250-57-22-33-131(250)179(306)232-111(61-95-37-43-99(256)44-38-95)163(290)235-120(188(315)316)62-96-39-45-100(257)46-40-96)244-138(263)74-212-157(284)112(64-134(195)259)228-173(300)122(78-317)238-164(291)110(60-94-35-41-98(255)42-36-94)227-167(294)116(69-145(274)275)231-168(295)117(70-146(276)277)229-162(289)109(59-85(3)4)226-166(293)115(68-144(272)273)230-165(292)113(66-142(268)269)218-137(262)73-210-155(282)103(27-17-51-205-189(197)198)219-153(280)90(9)215-158(285)104(28-18-52-206-190(199)200)221-159(286)105(29-19-53-207-191(201)202)222-172(299)126(82-321)242-182(309)148(87(6)14-2)246-184(311)149(92(11)253)245-139(264)75-211-156(283)107(48-50-141(266)267)223-171(298)124(80-319)241-180(307)132-34-23-56-249(132)185(312)118(63-97-72-209-102-26-16-15-25-101(97)102)233-174(301)123(79-318)239-175(302)125(81-320)240-177(304)129-31-21-55-248(129)140(265)76-213-151(278)88(7)217-183(310)150(93(12)254)247-176(303)127(83-322)237-161(288)108(47-49-133(194)258)220-152(279)89(8)214-136(261)71-193/h15-16,25-26,35-46,72,85-93,103-132,147-150,209,252-257,317-323H,13-14,17-24,27-34,47-71,73-84,193H2,1-12H3,(H2,194,258)(H2,195,259)(H2,196,260)(H,210,282)(H,211,283)(H,212,284)(H,213,278)(H,214,261)(H,215,285)(H,216,297)(H,217,310)(H,218,262)(H,219,280)(H,220,279)(H,221,286)(H,222,299)(H,223,298)(H,224,305)(H,225,281)(H,226,293)(H,227,294)(H,228,300)(H,229,289)(H,230,292)(H,231,295)(H,232,306)(H,233,301)(H,234,287)(H,235,290)(H,236,308)(H,237,288)(H,238,291)(H,239,302)(H,240,304)(H,241,307)(H,242,309)(H,243,296)(H,244,263)(H,245,264)(H,246,311)(H,247,303)(H,266,267)(H,268,269)(H,270,271)(H,272,273)(H,274,275)(H,276,277)(H,315,316)(H4,197,198,205)(H4,199,200,206)(H4,201,202,207)(H4,203,204,208)/t86-,87-,88-,89-,90-,91-,92+,93+,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,147-,148-,149-,150-/m0/s1

InChIKey=JDAUVQHCPJCGSH-WDPIKZKMSA-N


Database reference: