BIOPEP-UWM: Report

ID 4004
Name
sequence
RPKPQQFFFGLMG

Function:
 
Number of residues
13
Activity code
ne
Activity :
neuropeptide
Chemical mass 1552.8367 Monoisotopic mass 1551.7996
EC50 :
0.00 µM



Bibliographic data:
Authors
De Araujo J. E. et al.
Title
Anxiogenic effects of substance P and its 7-11 C-terminal, but not the 1-7 N-terminal, injected into the dorsal periaqueductal gray.Peptides, 20, 1437-1443
Year Source
1999 Journal



Additional information:
BIOPEP-UWM database of bioactive peptides

SMILES: [H][C@](N)(CCCNC(N)=N)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CCCCN)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)NCC(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCSC)C(=O)NCC(O)=O

InChI=1S/C74H109N19O16S/c1-44(2)38-53(67(103)86-51(32-37-110-3)63(99)83-43-62(97)98)84-61(96)42-82-64(100)54(39-45-18-7-4-8-19-45)89-68(104)56(41-47-22-11-6-12-23-47)91-69(105)55(40-46-20-9-5-10-21-46)90-66(102)49(28-30-59(77)94)85-65(101)50(29-31-60(78)95)87-70(106)58-27-17-36-93(58)73(109)52(25-13-14-33-75)88-71(107)57-26-16-35-92(57)72(108)48(76)24-15-34-81-74(79)80/h4-12,18-23,44,48-58H,13-17,24-43,75-76H2,1-3H3,(H2,77,94)(H2,78,95)(H,82,100)(H,83,99)(H,84,96)(H,85,101)(H,86,103)(H,87,106)(H,88,107)(H,89,104)(H,90,102)(H,91,105)(H,97,98)(H4,79,80,81)/t48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,58-/m0/s1

InChIKey=XFJGEHCZDNNSIC-HWLIXZHZSA-N



Mechanism of C-terminal amidation of peptides is reviewed in:
Bradbury A. F., Smyth D. G., Peptide amidation. Trends Biochem. Sci., 16, 1991, 112-115.



Database reference: