BIOPEP-UWM: Report

ID 4019
Name Rhodostomin
sequence
GKECDCSSPENPCCDAATCKLRPGAQCGEGLCCEQCKFSRAGKICRIPRGDMPDDRCTGQSADCPRYH
Function:
 
Number of residues
68
Activity code
at
Activity :
antithrombotic
Chemical mass 7330.2692 Monoisotopic mass 7325.0909
EC50 :
0.00 µM


Bibliographic data:
Authors
Huang T. F. et al.
Title
Trigramin, a low molecular weight peptide inhibiting fibrinogen interaction with platelet receptors expressed on glycoprotein IIb-IIIa complex.J. Biol. Chem., 262, 16157-16163
Year Source
1987 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides

SMILES: [H][C@](C)(O)[C@]([H])(NC(=O)[C@]([H])(CS)NC(=O)[C@]([H])(CCCNC(N)=N)NC(=O)[C@]([H])(CC(O)=O)NC(=O)[C@]([H])(CC(O)=O)NC(=O)[C@]1([H])CCCN1C(=O)[C@]([H])(CCSC)NC(=O)[C@]([H])(CC(O)=O)NC(=O)CNC(=O)[C@]([H])(CCCNC(N)=N)NC(=O)[C@]1([H])CCCN1C(=O)[C@@]([H])(NC(=O)[C@]([H])(CCCNC(N)=N)NC(=O)[C@]([H])(CS)NC(=O)[C@@]([H])(NC(=O)[C@]([H])(CCCCN)NC(=O)CNC(=O)[C@]([H])(C)NC(=O)[C@]([H])(CCCNC(N)=N)NC(=O)[C@]([H])(CO)NC(=O)[C@]([H])(Cc1ccccc1)NC(=O)[C@]([H])(CCCCN)NC(=O)[C@]([H])(CS)NC(=O)[C@]([H])(CCC(N)=O)NC(=O)[C@]([H])(CCC(O)=O)NC(=O)[C@]([H])(CS)NC(=O)[C@]([H])(CS)NC(=O)[C@]([H])(CC(C)C)NC(=O)CNC(=O)[C@]([H])(CCC(O)=O)NC(=O)CNC(=O)[C@]([H])(CS)NC(=O)[C@]([H])(CCC(N)=O)NC(=O)[C@]([H])(C)NC(=O)CNC(=O)[C@]1([H])CCCN1C(=O)[C@]([H])(CCCNC(N)=N)NC(=O)[C@]([H])(CC(C)C)NC(=O)[C@]([H])(CCCCN)NC(=O)[C@]([H])(CS)NC(=O)[C@@]([H])(NC(=O)[C@]([H])(C)NC(=O)[C@]([H])(C)NC(=O)[C@]([H])(CC(O)=O)NC(=O)[C@]([H])(CS)NC(=O)[C@]([H])(CS)NC(=O)[C@]1([H])CCCN1C(=O)[C@]([H])(CC(N)=O)NC(=O)[C@]([H])(CCC(O)=O)NC(=O)[C@]1([H])CCCN1C(=O)[C@]([H])(CO)NC(=O)[C@]([H])(CO)NC(=O)[C@]([H])(CS)NC(=O)[C@]([H])(CC(O)=O)NC(=O)[C@]([H])(CS)NC(=O)[C@]([H])(CCC(O)=O)NC(=O)[C@]([H])(CCCCN)NC(=O)CN)[C@@]([H])(C)O)[C@@]([H])(C)CC)[C@@]([H])(C)CC)C(=O)NCC(=O)N[C@@]([H])(CCC(N)=O)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CC(O)=O)C(=O)N[C@@]([H])(CS)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CCCNC(N)=N)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]cn1)C(O)=O

InChI=1S/C291H470N96O100S13/c1-17-135(7)221(277(478)375-190(128-496)262(463)343-156(52-34-87-318-290(309)310)246(447)379-222(136(8)18-2)284(485)387-94-41-59-199(387)273(474)347-148(48-30-83-314-286(301)302)230(431)321-114-210(405)337-170(102-215(414)415)252(453)351-165(78-95-500-16)280(481)383-90-37-57-197(383)274(475)359-175(107-220(424)425)254(455)356-173(105-218(420)421)253(454)339-154(50-32-85-316-288(305)306)238(439)369-192(130-498)269(470)381-223(142(14)392)276(477)325-115-208(403)335-158(64-71-200(297)395)239(440)362-178(116-388)257(458)331-140(12)228(429)352-172(104-217(418)419)256(457)377-193(131-499)283(484)386-93-40-56-196(386)271(472)348-155(51-33-86-317-289(307)308)237(438)355-169(99-145-60-62-147(394)63-61-145)250(451)361-177(285(486)487)100-146-109-313-132-326-146)378-245(446)150(45-23-27-80-293)333-206(401)111-320-225(426)137(9)329-233(434)153(49-31-84-315-287(303)304)340-258(459)179(117-389)363-251(452)168(98-144-42-20-19-21-43-144)354-236(437)152(47-25-29-82-295)341-260(461)183(121-489)367-243(444)160(66-73-202(299)397)344-240(441)161(68-75-212(408)409)346-261(462)184(122-490)372-267(468)188(126-494)370-248(449)166(96-133(3)4)336-209(404)113-322-231(432)157(67-74-211(406)407)334-207(402)112-323-232(433)182(120-488)366-242(443)159(65-72-201(298)396)338-227(428)138(10)327-205(400)110-324-270(471)194-54-36-89-382(194)279(480)164(53-35-88-319-291(311)312)350-249(450)167(97-134(5)6)353-235(436)151(46-24-28-81-294)342-263(464)191(129-497)376-278(479)224(143(15)393)380-229(430)141(13)328-226(427)139(11)330-247(448)171(103-216(416)417)357-265(466)186(124-492)373-268(469)189(127-495)374-275(476)198-58-38-91-384(198)281(482)176(101-203(300)398)360-241(442)163(70-77-214(412)413)349-272(473)195-55-39-92-385(195)282(483)181(119-391)365-259(460)180(118-390)364-266(467)187(125-493)371-255(456)174(106-219(422)423)358-264(465)185(123-491)368-244(445)162(69-76-213(410)411)345-234(435)149(44-22-26-79-292)332-204(399)108-296/h19-21,42-43,60-63,109,132-143,148-199,221-224,388-394,488-499H,17-18,22-41,44-59,64-108,110-131,292-296H2,1-16H3,(H2,297,395)(H2,298,396)(H2,299,397)(H2,300,398)(H,313,326)(H,320,426)(H,321,431)(H,322,432)(H,323,433)(H,324,471)(H,325,477)(H,327,400)(H,328,427)(H,329,434)(H,330,448)(H,331,458)(H,332,399)(H,333,401)(H,334,402)(H,335,403)(H,336,404)(H,337,405)(H,338,428)(H,339,454)(H,340,459)(H,341,461)(H,342,464)(H,343,463)(H,344,441)(H,345,435)(H,346,462)(H,347,474)(H,348,472)(H,349,473)(H,350,450)(H,351,453)(H,352,429)(H,353,436)(H,354,437)(H,355,438)(H,356,455)(H,357,466)(H,358,465)(H,359,475)(H,360,442)(H,361,451)(H,362,440)(H,363,452)(H,364,467)(H,365,460)(H,366,443)(H,367,444)(H,368,445)(H,369,439)(H,370,449)(H,371,456)(H,372,468)(H,373,469)(H,374,476)(H,375,478)(H,376,479)(H,377,457)(H,378,446)(H,379,447)(H,380,430)(H,381,470)(H,406,407)(H,408,409)(H,410,411)(H,412,413)(H,414,415)(H,416,417)(H,418,419)(H,420,421)(H,422,423)(H,424,425)(H,486,487)(H4,301,302,314)(H4,303,304,315)(H4,305,306,316)(H4,307,308,317)(H4,309,310,318)(H4,311,312,319)/t135-,136-,137-,138-,139-,140-,141-,142+,143+,148-,149-,150-,151-,152-,153-,154-,155-,156-,157-,158-,159-,160-,161-,162-,163-,164-,165-,166-,167-,168-,169-,170-,171-,172-,173-,174-,175-,176-,177-,178-,179-,180-,181-,182-,183-,184-,185-,186-,187-,188-,189-,190-,191-,192-,193-,194-,195-,196-,197-,198-,199-,221-,222-,223-,224-/m0/s1

InChIKey=FZURMTNBXMZZCS-FWZKYCSMSA-N



Peptide belongs to the disintegrin family. For a review see: Huang T. F., Liu C. Z., The biological activity of disintegrins and their possible applications. J. Toxicol. Toxin Rev., 16, 1997, 135-161. Mechanisms of integrin-mediated adhesion processes have been reviewed in: Giancotti F. G., Ruoslahti E., Signal transduction - integrin signalling. Science, 285, 1999, 1028-1035. Molecular mass calculated for reduced form


Database reference: