BIOPEP-UWM: Report

ID 4020
Name Arietin
sequence
VSPPVCGNKILEQGEDCDCGSPANCQDQCCNAATCKLTPGSQCNHGECCDQCKFKKARTVCRIARGDWNDDYCTGKSSDCPWNH
Function:
 
Number of residues
84
Activity code
at
Activity :
antithrombotic
Chemical mass 9120.0980 Monoisotopic mass 9113.7934
EC50 :
0.00 µM


Bibliographic data:
Authors
Huang T. F. et al.
Title
Trigramin, a low molecular weight peptide inhibiting fibrinogen interaction with platelet receptors expressed on glycoprotein IIb-IIIa complex.J. Biol. Chem., 262, 16157-16163
Year Source
1987 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides

SMILES: [H][C@](C)(O)[C@]([H])(NC(=O)[C@]([H])(CS)NC(=O)[C@]([H])(Cc1ccc(O)cc1)NC(=O)[C@]([H])(CC(O)=O)NC(=O)[C@]([H])(CC(O)=O)NC(=O)[C@]([H])(CC(N)=O)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@]([H])(CC(O)=O)NC(=O)CNC(=O)[C@]([H])(CCCNC(N)=N)NC(=O)[C@]([H])(C)NC(=O)[C@@]([H])(NC(=O)[C@]([H])(CCCNC(N)=N)NC(=O)[C@]([H])(CS)NC(=O)[C@@]([H])(NC(=O)[C@@]([H])(NC(=O)[C@]([H])(CCCNC(N)=N)NC(=O)[C@]([H])(C)NC(=O)[C@]([H])(CCCCN)NC(=O)[C@]([H])(CCCCN)NC(=O)[C@]([H])(Cc1ccccc1)NC(=O)[C@]([H])(CCCCN)NC(=O)[C@]([H])(CS)NC(=O)[C@]([H])(CCC(N)=O)NC(=O)[C@]([H])(CC(O)=O)NC(=O)[C@]([H])(CS)NC(=O)[C@]([H])(CS)NC(=O)[C@]([H])(CCC(O)=O)NC(=O)CNC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@]([H])(CC(N)=O)NC(=O)[C@]([H])(CS)NC(=O)[C@]([H])(CCC(N)=O)NC(=O)[C@]([H])(CO)NC(=O)CNC(=O)[C@]1([H])CCCN1C(=O)[C@@]([H])(NC(=O)[C@]([H])(CC(C)C)NC(=O)[C@]([H])(CCCCN)NC(=O)[C@]([H])(CS)NC(=O)[C@@]([H])(NC(=O)[C@]([H])(C)NC(=O)[C@]([H])(C)NC(=O)[C@]([H])(CC(N)=O)NC(=O)[C@]([H])(CS)NC(=O)[C@]([H])(CS)NC(=O)[C@]([H])(CCC(N)=O)NC(=O)[C@]([H])(CC(O)=O)NC(=O)[C@]([H])(CCC(N)=O)NC(=O)[C@]([H])(CS)NC(=O)[C@]([H])(CC(N)=O)NC(=O)[C@]([H])(C)NC(=O)[C@]1([H])CCCN1C(=O)[C@]([H])(CO)NC(=O)CNC(=O)[C@]([H])(CS)NC(=O)[C@]([H])(CC(O)=O)NC(=O)[C@]([H])(CS)NC(=O)[C@]([H])(CC(O)=O)NC(=O)[C@]([H])(CCC(O)=O)NC(=O)CNC(=O)[C@]([H])(CCC(N)=O)NC(=O)[C@]([H])(CCC(O)=O)NC(=O)[C@]([H])(CC(C)C)NC(=O)[C@@]([H])(NC(=O)[C@]([H])(CCCCN)NC(=O)[C@]([H])(CC(N)=O)NC(=O)CNC(=O)[C@]([H])(CS)NC(=O)[C@@]([H])(NC(=O)[C@]1([H])CCCN1C(=O)[C@]1([H])CCCN1C(=O)[C@]([H])(CO)NC(=O)[C@@]([H])(N)C(C)C)C(C)C)[C@@]([H])(C)CC)[C@@]([H])(C)O)[C@@]([H])(C)O)[C@@]([H])(C)O)C(C)C)[C@@]([H])(C)CC)C(=O)NCC(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CC(O)=O)C(=O)N[C@@]([H])(CS)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@]([H])(CC(N)=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(O)=O

InChI=1S/C368H574N116O128S14/c1-24-166(13)283(356(602)413-171(18)291(537)421-188(65-45-99-395-366(387)388)294(540)400-135-266(510)418-218(121-272(519)520)325(571)439-209(111-179-129-398-186-57-31-29-55-184(179)186)318(564)441-215(118-259(383)503)322(568)447-222(125-276(527)528)329(575)448-221(124-275(525)526)328(574)438-208(110-178-73-75-183(494)76-74-178)317(563)465-244(157-625)347(593)477-285(173(20)490)353(599)406-139-264(508)414-189(59-33-39-93-369)300(546)455-229(142-487)336(582)456-228(141-486)335(581)449-225(128-279(533)534)332(578)471-245(158-626)362(608)481-103-50-70-248(481)350(596)452-210(112-180-130-399-187-58-32-30-56-185(180)187)319(565)442-217(120-261(385)505)323(569)454-226(365(611)612)114-182-132-394-160-408-182)474-312(558)196(67-47-101-397-368(391)392)428-339(585)242(155-623)469-355(601)282(165(11)12)473-359(605)287(175(22)492)478-313(559)195(66-46-100-396-367(389)390)422-290(536)169(16)410-299(545)190(60-34-40-94-370)423-301(547)191(61-35-41-95-371)424-316(562)207(109-177-53-27-26-28-54-177)437-303(549)193(63-37-43-97-373)426-337(583)234(147-615)460-308(554)201(79-87-253(377)497)431-327(573)220(123-274(523)524)450-344(590)239(152-620)467-345(591)240(153-621)459-305(551)199(83-91-270(515)516)416-263(507)134-402-296(542)211(113-181-131-393-159-407-181)440-321(567)216(119-260(384)504)444-341(587)236(149-617)461-310(556)203(81-89-255(379)499)433-334(580)227(140-485)419-267(511)138-405-348(594)246-68-48-105-483(246)364(610)288(176(23)493)479-333(579)206(108-162(5)6)436-302(548)192(62-36-42-96-372)427-340(586)243(156-624)470-358(604)286(174(21)491)476-293(539)172(19)409-289(535)168(15)411-314(560)213(116-257(381)501)443-342(588)238(151-619)466-346(592)241(154-622)462-309(555)202(80-88-254(378)498)430-326(572)219(122-273(521)522)446-307(553)200(78-86-252(376)496)434-338(584)235(148-616)463-324(570)214(117-258(382)502)435-292(538)170(17)412-349(595)247-69-49-102-480(247)360(606)230(143-488)420-268(512)137-404-297(543)232(145-613)458-330(576)224(127-278(531)532)451-343(589)237(150-618)464-331(577)223(126-277(529)530)445-304(550)198(82-90-269(513)514)415-262(506)133-401-295(541)197(77-85-251(375)495)429-306(552)204(84-92-271(517)518)432-315(561)205(107-161(3)4)453-357(603)284(167(14)25-2)475-311(557)194(64-38-44-98-374)425-320(566)212(115-256(380)500)417-265(509)136-403-298(544)233(146-614)468-354(600)281(164(9)10)472-351(597)249-71-51-104-482(249)363(609)250-72-52-106-484(250)361(607)231(144-489)457-352(598)280(386)163(7)8/h26-32,53-58,73-76,129-132,159-176,188-250,280-288,398-399,485-494,613-626H,24-25,33-52,59-72,77-128,133-158,369-374,386H2,1-23H3,(H2,375,495)(H2,376,496)(H2,377,497)(H2,378,498)(H2,379,499)(H2,380,500)(H2,381,501)(H2,382,502)(H2,383,503)(H2,384,504)(H2,385,505)(H,393,407)(H,394,408)(H,400,540)(H,401,541)(H,402,542)(H,403,544)(H,404,543)(H,405,594)(H,406,599)(H,409,535)(H,410,545)(H,411,560)(H,412,595)(H,413,602)(H,414,508)(H,415,506)(H,416,507)(H,417,509)(H,418,510)(H,419,511)(H,420,512)(H,421,537)(H,422,536)(H,423,547)(H,424,562)(H,425,566)(H,426,583)(H,427,586)(H,428,585)(H,429,552)(H,430,572)(H,431,573)(H,432,561)(H,433,580)(H,434,584)(H,435,538)(H,436,548)(H,437,549)(H,438,574)(H,439,571)(H,440,567)(H,441,564)(H,442,565)(H,443,588)(H,444,587)(H,445,550)(H,446,553)(H,447,568)(H,448,575)(H,449,581)(H,450,590)(H,451,589)(H,452,596)(H,453,603)(H,454,569)(H,455,546)(H,456,582)(H,457,598)(H,458,576)(H,459,551)(H,460,554)(H,461,556)(H,462,555)(H,463,570)(H,464,577)(H,465,563)(H,466,592)(H,467,591)(H,468,600)(H,469,601)(H,470,604)(H,471,578)(H,472,597)(H,473,605)(H,474,558)(H,475,557)(H,476,539)(H,477,593)(H,478,559)(H,479,579)(H,513,514)(H,515,516)(H,517,518)(H,519,520)(H,521,522)(H,523,524)(H,525,526)(H,527,528)(H,529,530)(H,531,532)(H,533,534)(H,611,612)(H4,387,388,395)(H4,389,390,396)(H4,391,392,397)/t166-,167-,168-,169-,170-,171-,172-,173+,174+,175+,176+,188-,189-,190-,191-,192-,193-,194-,195-,196-,197-,198-,199-,200-,201-,202-,203-,204-,205-,206-,207-,208-,209-,210-,211-,212-,213-,214-,215-,216-,217-,218-,219-,220-,221-,222-,223-,224-,225-,226-,227-,228-,229-,230-,231-,232-,233-,234-,235-,236-,237-,238-,239-,240-,241-,242-,243-,244-,245-,246-,247-,248-,249-,250-,280-,281-,282-,283-,284-,285-,286-,287-,288-/m0/s1

InChIKey=OQZZDCIWPBRBJM-JIESHDBMSA-N



Peptide belongs to the disintegrin family. For a review see: Huang T. F., Liu C. Z., The biological activity of disintegrins and their possible applications. J. Toxicol. Toxin Rev., 16, 1997, 135-161. Mechanisms of integrin-mediated adhesion processes have been reviewed in: Giancotti F. G., Ruoslahti E., Signal transduction - integrin signalling. Science, 285, 1999, 1028-1035. Molecular mass calculated for reduced form


Database reference: