BIOPEP-UWM: Report

ID 5345
Name Indolicidin precursor
sequence
ILPWKWPWWPWRRG
Function:
Precursor of antibacterial peptide
 
Number of residues
14
Activity code
ab
Activity :
antibacterial
Chemical mass 1964.3152 Monoisotopic mass 1963.0493
EC50 :
0.00 µM


Bibliographic data:
Authors
Selsted M. E., Novotny M. J ., Morris W. L., Tang Y.-Q., Smith W., Cullor J. S.
Title
Indolicidin, a novel bactericidal tridecapeptide amide from neutrophils. J. Biol. Chem. 267, 4292-4295, 1992
Year Source
1992 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides

SMILES: N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@H](Cc1c[nH]c2c1cccc2)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@H](Cc1c[nH]c2c1cccc2)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@H](Cc1c[nH]c2c1cccc2)C(=O)N[C@@H](Cc1c[nH]c2c1cccc2)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@H](Cc1c[nH]c2c1cccc2)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)NCC(=O)O

InChI=1S/C102H134N26O15/c1-5-58(4)87(104)97(140)125-80(45-57(2)3)98(141)126-42-20-36-83(126)94(137)120-77(46-59-51-111-69-28-11-6-23-64(59)69)91(134)118-75(33-16-17-39-103)90(133)123-81(49-62-54-114-72-31-14-9-26-67(62)72)99(142)127-43-21-38-85(127)96(139)122-79(48-61-53-113-71-30-13-8-25-66(61)71)93(136)124-82(50-63-55-115-73-32-15-10-27-68(63)73)100(143)128-44-22-37-84(128)95(138)121-78(47-60-52-112-70-29-12-7-24-65(60)70)92(135)119-76(35-19-41-110-102(107)108)89(132)117-74(34-18-40-109-101(105)106)88(131)116-56-86(129)130/h6-15,23-32,51-55,57-58,74-85,87,111-115H,5,16-22,33-50,56,103-104H2,1-4H3,(H,116,131)(H,117,132)(H,118,134)(H,119,135)(H,120,137)(H,121,138)(H,122,139)(H,123,133)(H,124,136)(H,125,140)(H,129,130)(H4,105,106,109)(H4,107,108,110)/t58-,74-,75-,76-,77-,78-,79-,80-,81-,82-,83-,84-,85-,87-/m0/s1

InChIKey=BCUCGMPRWGHLSG-DHOIYGIPSA-N


The active form of this peptide contains C-terminal amide group instead of C-terminal glycine residue.

Peptide is the precursor of antibacterial peptide (ID 3053 in BIOPEP-UWM database of bioactive peptides).

Reviews concerning C-terminal amidation of peptides:

Bradbury A. F., Smyth D. G., 1991, Peptide amidation. Trends Biochem. Sci., 16, 112-115

Merkler D. J., 1994, C-terminal amidated peptides: production by the in vitro enzymatic amidation of glycine-extended peptides and the importance of the amide to bioactivity. Enzyme Microb. Technol., 16, 450-456


Database reference: