BIOPEP-UWM: Report

ID 5346
Name Abaecin
sequence
VPLPNVPQPGRRPFPTFPGQGPFNPKIKWPQGY
Function:
This peptide has bactericidal activity.
 
Number of residues
33
Activity code
ab
Activity :
antibacterial
Chemical mass 3715.2568 Monoisotopic mass 3712.9724
EC50 :
0.00 µM


Bibliographic data:
Authors
Casteels-Josson K., Zhang W., Capaci T., Casteels P., Tempst P.;
Title
"Acute transcriptional response of the honeybee peptide-antibiotics gene repertoire and required post-translational conversion of the precursor structures."; J. Biol. Chem. 269:28569-28575(1994).
Year Source
1994 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides

SMILES: [H][C@](C)(O)[C@]([H])(NC(=O)[C@]1([H])CCCN1C(=O)[C@]([H])(Cc1ccccc1)NC(=O)[C@]1([H])CCCN1C(=O)[C@]([H])(CCCNC(N)=N)NC(=O)[C@]([H])(CCCNC(N)=N)NC(=O)CNC(=O)[C@]1([H])CCCN1C(=O)[C@]([H])(CCC(N)=O)NC(=O)[C@]1([H])CCCN1C(=O)[C@@]([H])(NC(=O)[C@]([H])(CC(N)=O)NC(=O)[C@]1([H])CCCN1C(=O)[C@]([H])(CC(C)C)NC(=O)[C@]1([H])CCCN1C(=O)[C@@]([H])(N)C(C)C)C(C)C)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N1CCC[C@@]1([H])C(=O)NCC(=O)N[C@@]([H])(CCC(N)=O)C(=O)NCC(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(CC(N)=O)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@]([H])(C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CCC(N)=O)C(=O)NCC(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(O)=O)[C@@]([H])(C)CC

InChI=1S/C178H261N47O41/c1-10-100(8)146(165(254)203-111(46-22-24-70-179)151(240)208-122(89-106-92-193-109-45-21-20-44-108(106)109)172(261)221-79-32-54-129(221)159(248)202-114(65-68-136(182)229)149(238)194-93-142(235)200-124(176(265)266)88-105-60-62-107(227)63-61-105)214-152(241)112(47-23-25-71-180)201-158(247)128-53-33-80-222(128)173(262)123(91-139(185)232)209-153(242)117(85-102-38-14-11-15-39-102)206-157(246)127-52-28-74-216(127)143(236)96-197-148(237)113(64-67-135(181)228)199-141(234)95-196-156(245)126-51-30-76-218(126)171(260)121(87-104-42-18-13-19-43-104)212-166(255)147(101(9)226)215-164(253)134-59-35-81-223(134)170(259)120(86-103-40-16-12-17-41-103)211-162(251)131-56-31-77-219(131)167(256)115(49-27-73-192-178(189)190)204-150(239)110(48-26-72-191-177(187)188)198-140(233)94-195-155(244)125-50-29-75-217(125)168(257)116(66-69-137(183)230)205-160(249)133-58-37-83-225(133)175(264)145(99(6)7)213-154(243)118(90-138(184)231)207-161(250)130-55-34-78-220(130)169(258)119(84-97(2)3)210-163(252)132-57-36-82-224(132)174(263)144(186)98(4)5/h11-21,38-45,60-63,92,97-101,110-134,144-147,193,226-227H,10,22-37,46-59,64-91,93-96,179-180,186H2,1-9H3,(H2,181,228)(H2,182,229)(H2,183,230)(H2,184,231)(H2,185,232)(H,194,238)(H,195,244)(H,196,245)(H,197,237)(H,198,233)(H,199,234)(H,200,235)(H,201,247)(H,202,248)(H,203,254)(H,204,239)(H,205,249)(H,206,246)(H,207,250)(H,208,240)(H,209,242)(H,210,252)(H,211,251)(H,212,255)(H,213,243)(H,214,241)(H,215,253)(H,265,266)(H4,187,188,191)(H4,189,190,192)/t100-,101+,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,144-,145-,146-,147-/m0/s1

InChIKey=JQGUOLAPUTVKDO-YMQMXGOSSA-N


Database reference:
SWISS-PROT ABAE_APIME