BIOPEP-UWM: Report

ID 5351
Name Royalisin
sequence
VTCDLLSFKGQVNDSACAANCLSLGKAGGHCEKVGCICRKTSFKDLWDKRFG
Function:
Found in royal jelly, potent antibacterial protein against gram-positive bacteria at low concentration. Its biological activity is likely to be related to its ability to interact with the bacterial membrane.
 
Number of residues
52
Activity code
ab
Activity :
antibacterial
Chemical mass 5582.4133 Monoisotopic mass 5578.6776
EC50 :
0.00 µM


Bibliographic data:
Authors
Fujiwara S., Imai J., Fujiwara M., Yaeshima T., Kawashima T., Kobayashi K.;
Title
"A potent antibacterial protein in royal jelly. Purification and determination of the primary structure of royalisin."; J. Biol. Chem. 265:11333-11337.
Year Source
1990 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides

SMILES: [H][C@](C)(O)[C@]([H])(NC(=O)[C@@]([H])(N)C(C)C)C(=O)N[C@@]([H])(CS)C(=O)N[C@@]([H])(CC(O)=O)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(CCCCN)C(=O)NCC(=O)N[C@@]([H])(CCC(N)=O)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CC(N)=O)C(=O)N[C@@]([H])(CC(O)=O)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CS)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CC(N)=O)C(=O)N[C@@]([H])(CS)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CC(C)C)C(=O)NCC(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(C)C(=O)NCC(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@]([H])(CS)C(=O)N[C@@]([H])(CCC(O)=O)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(C(C)C)C(=O)NCC(=O)N[C@@]([H])(CS)C(=O)N[C@]([H])(C(=O)N[C@@]([H])(CS)C(=O)N[C@@]([H])(CCCNC(N)=N)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@]([H])(C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CC(O)=O)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@]([H])(CC(O)=O)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CCCNC(N)=N)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)NCC(O)=O)[C@@]([H])(C)O)[C@@]([H])(C)CC

InChI=1S/C239H384N70O72S6/c1-25-122(18)189(235(379)303-170(111-386)228(372)279-142(65-49-77-255-238(250)251)201(345)274-141(64-42-48-76-245)206(350)308-190(127(23)314)236(380)299-165(106-313)225(369)289-153(86-131-55-33-28-34-56-131)213(357)277-139(62-40-46-74-243)202(346)291-159(92-182(328)329)219(363)285-148(81-116(6)7)209(353)290-154(87-132-95-257-135-58-36-35-57-134(132)135)214(358)292-158(91-181(326)327)218(362)278-138(61-39-45-73-242)200(344)276-143(66-50-78-256-239(252)253)203(347)287-151(198(342)263-102-185(334)335)84-129-51-29-26-30-52-129)307-231(375)166(107-382)272-179(323)101-262-233(377)187(120(14)15)305-205(349)140(63-41-47-75-244)275-204(348)145(68-70-180(324)325)280-227(371)168(109-384)301-215(359)155(88-133-96-254-113-264-133)271-176(320)98-258-175(319)97-259-192(336)123(19)266-199(343)137(60-38-44-72-241)269-177(321)100-261-197(341)146(79-114(2)3)282-223(367)163(104-311)297-211(355)150(83-118(10)11)286-229(373)169(110-385)302-217(361)156(89-173(247)317)281-194(338)125(21)265-193(337)124(20)268-226(370)167(108-383)300-195(339)126(22)267-222(366)162(103-310)296-221(365)161(94-184(332)333)293-216(360)157(90-174(248)318)295-234(378)188(121(16)17)306-207(351)144(67-69-172(246)316)270-178(322)99-260-196(340)136(59-37-43-71-240)273-212(356)152(85-130-53-31-27-32-54-130)288-224(368)164(105-312)298-210(354)149(82-117(8)9)283-208(352)147(80-115(4)5)284-220(364)160(93-183(330)331)294-230(374)171(112-387)304-237(381)191(128(24)315)309-232(376)186(249)119(12)13/h26-36,51-58,95-96,113-128,136-171,186-191,257,310-315,382-387H,25,37-50,59-94,97-112,240-245,249H2,1-24H3,(H2,246,316)(H2,247,317)(H2,248,318)(H,254,264)(H,258,319)(H,259,336)(H,260,340)(H,261,341)(H,262,377)(H,263,342)(H,265,337)(H,266,343)(H,267,366)(H,268,370)(H,269,321)(H,270,322)(H,271,320)(H,272,323)(H,273,356)(H,274,345)(H,275,348)(H,276,344)(H,277,357)(H,278,362)(H,279,372)(H,280,371)(H,281,338)(H,282,367)(H,283,352)(H,284,364)(H,285,363)(H,286,373)(H,287,347)(H,288,368)(H,289,369)(H,290,353)(H,291,346)(H,292,358)(H,293,360)(H,294,374)(H,295,378)(H,296,365)(H,297,355)(H,298,354)(H,299,380)(H,300,339)(H,301,359)(H,302,361)(H,303,379)(H,304,381)(H,305,349)(H,306,351)(H,307,375)(H,308,350)(H,309,376)(H,324,325)(H,326,327)(H,328,329)(H,330,331)(H,332,333)(H,334,335)(H4,250,251,255)(H4,252,253,256)/t122-,123-,124-,125-,126-,127+,128+,136-,137-,138-,139-,140-,141-,142-,143-,144-,145-,146-,147-,148-,149-,150-,151-,152-,153-,154-,155-,156-,157-,158-,159-,160-,161-,162-,163-,164-,165-,166-,167-,168-,169-,170-,171-,186-,187-,188-,189-,190-,191-/m0/s1

InChIKey=PYVPZXBVXJOFSA-ZPBBFGCOSA-N


Database reference:
SWISS-PROT DEFI_APIME