BIOPEP-UWM: Report

ID 5356
Name Antimicrobial peptide THP1
sequence
GKREKCLRRNGFCAFLKCPTLSVISGTCSRFQVCC
Function:
Bactericidal activity; inhibits Staphylococcus aureus and Escherichia coli.
 
Number of residues
35
Activity code
ab
Activity :
antibacterial
Chemical mass 3912.6746 Monoisotopic mass 3909.9171
EC50 :
0.00 µM


Bibliographic data:
Authors
Brockus C.W., Harmon B.G., Jackwood M.W
Title
"Characterization of beta-defensin prepropeptide mRNA from chicken and turkey bone marrow."; Anim. Genet. 29:283-289.
Year Source
1998 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides

SMILES: [H][C@](C)(O)[C@]([H])(NC(=O)CNC(=O)[C@]([H])(CO)NC(=O)[C@@]([H])(NC(=O)[C@@]([H])(NC(=O)[C@]([H])(CO)NC(=O)[C@]([H])(CC(C)C)NC(=O)[C@@]([H])(NC(=O)[C@]1([H])CCCN1C(=O)[C@]([H])(CS)NC(=O)[C@]([H])(CCCCN)NC(=O)[C@]([H])(CC(C)C)NC(=O)[C@]([H])(Cc1ccccc1)NC(=O)[C@]([H])(C)NC(=O)[C@]([H])(CS)NC(=O)[C@]([H])(Cc1ccccc1)NC(=O)CNC(=O)[C@]([H])(CC(N)=O)NC(=O)[C@]([H])(CCCNC(N)=N)NC(=O)[C@]([H])(CCCNC(N)=N)NC(=O)[C@]([H])(CC(C)C)NC(=O)[C@]([H])(CS)NC(=O)[C@]([H])(CCCCN)NC(=O)[C@]([H])(CCC(O)=O)NC(=O)[C@]([H])(CCCNC(N)=N)NC(=O)[C@]([H])(CCCCN)NC(=O)CN)[C@@]([H])(C)O)C(C)C)[C@@]([H])(C)CC)C(=O)N[C@@]([H])(CS)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CCCNC(N)=N)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CS)C(=O)N[C@@]([H])(CS)C(O)=O

InChI=1S/C166H276N52O45S6/c1-16-87(12)128(158(258)206-110(73-219)133(233)186-72-124(228)213-129(89(14)222)159(259)210-115(78-266)153(253)205-111(74-220)149(249)195-100(49-35-61-184-166(179)180)137(237)201-108(68-93-41-24-19-25-42-93)147(247)197-101(51-53-120(171)224)142(242)214-126(85(8)9)156(256)209-116(79-267)154(254)212-118(81-269)162(262)263)216-157(257)127(86(10)11)215-150(250)112(75-221)204-145(245)105(65-84(6)7)203-160(260)130(90(15)223)217-155(255)119-50-36-62-218(119)161(261)117(80-268)211-140(240)96(45-28-31-57-169)193-143(243)103(63-82(2)3)199-148(248)107(67-92-39-22-18-23-40-92)198-131(231)88(13)187-151(251)113(76-264)208-146(246)106(66-91-37-20-17-21-38-91)189-123(227)71-185-132(232)109(69-121(172)225)202-138(238)99(48-34-60-183-165(177)178)192-135(235)98(47-33-59-182-164(175)176)194-144(244)104(64-83(4)5)200-152(252)114(77-265)207-139(239)95(44-27-30-56-168)190-141(241)102(52-54-125(229)230)196-136(236)97(46-32-58-181-163(173)174)191-134(234)94(43-26-29-55-167)188-122(226)70-170/h17-25,37-42,82-90,94-119,126-130,219-223,264-269H,16,26-36,43-81,167-170H2,1-15H3,(H2,171,224)(H2,172,225)(H,185,232)(H,186,233)(H,187,251)(H,188,226)(H,189,227)(H,190,241)(H,191,234)(H,192,235)(H,193,243)(H,194,244)(H,195,249)(H,196,236)(H,197,247)(H,198,231)(H,199,248)(H,200,252)(H,201,237)(H,202,238)(H,203,260)(H,204,245)(H,205,253)(H,206,258)(H,207,239)(H,208,246)(H,209,256)(H,210,259)(H,211,240)(H,212,254)(H,213,228)(H,214,242)(H,215,250)(H,216,257)(H,217,255)(H,229,230)(H,262,263)(H4,173,174,181)(H4,175,176,182)(H4,177,178,183)(H4,179,180,184)/t87-,88-,89+,90+,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,126-,127-,128-,129-,130-/m0/s1

InChIKey=SHNGIXUQWBNUDA-OTTBVHJSSA-N


Database reference:
SWISS-PROT AMP1_MELGA