BIOPEP-UWM: Report

ID 5368
Name Sarcotoxin IC
sequence
GWLRKIGKKIERVGQHTRDATIQVLGIAQQAANVAATARG
Function:
Sarcotoxins, which are potent bactericidal proteins, are produced in response to injury. They are cytotoxic to both gram-positive and gram-negative bacteria. Belongs to the cecropin family.
 
Number of residues
40
Activity code
ab
Activity :
antibacterial
Chemical mass 4283.8848 Monoisotopic mass 4281.3976
EC50 :
0.00 µM


Bibliographic data:
Authors
Okada M., Natori S.;
Title
"Primary structure of sarcotoxin I, an antibacterial protein induced in the hemolymph of Sarcophaga peregrina (flesh fly) larvae."; J. Biol. Chem. 260:7174-7177.
Year Source
1985 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides

SMILES: [H][C@](C)(O)[C@]([H])(NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@]([H])(CCC(N)=O)NC(=O)CNC(=O)[C@@]([H])(NC(=O)[C@]([H])(CCCNC(N)=N)NC(=O)[C@]([H])(CCC(O)=O)NC(=O)[C@@]([H])(NC(=O)[C@]([H])(CCCCN)NC(=O)[C@]([H])(CCCCN)NC(=O)CNC(=O)[C@@]([H])(NC(=O)[C@]([H])(CCCCN)NC(=O)[C@]([H])(CCCNC(N)=N)NC(=O)[C@]([H])(CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN)[C@@]([H])(C)CC)[C@@]([H])(C)CC)C(C)C)C(=O)N[C@@]([H])(CCCNC(N)=N)C(=O)N[C@@]([H])(CC(O)=O)C(=O)N[C@@]([H])(C)C(=O)N[C@]([H])(C(=O)N[C@]([H])(C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)NCC(=O)N[C@]([H])(C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CC(N)=O)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C)C(=O)N[C@]([H])(C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCCNC(N)=N)C(=O)NCC(O)=O)[C@@]([H])(C)O)[C@@]([H])(C)CC)[C@@]([H])(C)CC)[C@@]([H])(C)O

InChI=1S/C186H317N63O53/c1-29-90(15)141(244-165(285)110(48-36-39-65-188)228-159(279)112(51-42-68-206-184(198)199)230-169(289)121(72-86(7)8)236-170(290)122(224-131(258)77-190)73-104-78-209-107-46-34-33-45-106(104)107)174(294)212-81-132(259)222-109(47-35-38-64-187)158(278)227-111(49-37-40-66-189)166(286)245-143(92(17)31-3)178(298)234-119(58-63-135(262)263)163(283)229-114(53-44-70-208-186(202)203)164(284)241-138(87(9)10)173(293)211-80-133(260)223-115(54-59-126(191)253)161(281)237-123(74-105-79-204-84-214-105)171(291)249-146(102(27)251)181(301)232-113(52-43-69-207-185(200)201)160(280)238-125(76-136(264)265)168(288)218-100(25)154(274)248-147(103(28)252)182(302)246-144(93(18)32-4)179(299)233-118(57-62-129(194)256)167(287)242-140(89(13)14)176(296)239-120(71-85(5)6)156(276)210-82-134(261)240-142(91(16)30-2)177(297)220-97(22)151(271)226-117(56-61-128(193)255)162(282)231-116(55-60-127(192)254)157(277)217-94(19)148(268)215-96(21)152(272)235-124(75-130(195)257)172(292)243-139(88(11)12)175(295)219-95(20)149(269)216-99(24)153(273)247-145(101(26)250)180(300)221-98(23)150(270)225-108(50-41-67-205-183(196)197)155(275)213-83-137(266)267/h33-34,45-46,78-79,84-103,108-125,138-147,209,250-252H,29-32,35-44,47-77,80-83,187-190H2,1-28H3,(H2,191,253)(H2,192,254)(H2,193,255)(H2,194,256)(H2,195,257)(H,204,214)(H,210,276)(H,211,293)(H,212,294)(H,213,275)(H,215,268)(H,216,269)(H,217,277)(H,218,288)(H,219,295)(H,220,297)(H,221,300)(H,222,259)(H,223,260)(H,224,258)(H,225,270)(H,226,271)(H,227,278)(H,228,279)(H,229,283)(H,230,289)(H,231,282)(H,232,301)(H,233,299)(H,234,298)(H,235,272)(H,236,290)(H,237,281)(H,238,280)(H,239,296)(H,240,261)(H,241,284)(H,242,287)(H,243,292)(H,244,285)(H,245,286)(H,246,302)(H,247,273)(H,248,274)(H,249,291)(H,262,263)(H,264,265)(H,266,267)(H4,196,197,205)(H4,198,199,206)(H4,200,201,207)(H4,202,203,208)/t90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101+,102+,103+,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,138-,139-,140-,141-,142-,143-,144-,145-,146-,147-/m0/s1

InChIKey=DUUSGUDQJALALW-IVGDNNQWSA-N


Database reference:
SWISS-PROT: SR1C_SARPE