BIOPEP-UWM: Report

ID 5372
Name dermaseptin B3
sequence
ALWKNMLKGIGKLAGQAALGAVKTLVGAEG
Function:
Possesses a potent antimicrobial activity against gram-positive and gram-negative bacteria. Probably acts by disturbing membrane functions with its amphipathic structure.
 
Number of residues
30
Activity code
ab
Activity :
antibacterial
Chemical mass 2966.5353 Monoisotopic mass 2964.6894
EC50 :
0.00 µM


Bibliographic data:
Authors
Charpentier S., Amiche M., Mester J., Vouille V., Le Caer J.-P., Nicolas P., Delfour A
Title
"Structure, synthesis, and molecular cloning of dermaseptins B, a family of skin peptide antibiotics.";J.Biol. Chem. 273:14690-14697(1998).
Year Source
1998 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: N[C@@]([H])(C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2c1cccc2)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(CCSC)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCCCN)C(=O)NCC(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)NCC(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C)C(=O)NCC(=O)N[C@@]([H])(CCC(=O)N)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CC(C)C)C(=O)NCC(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C(C)C)C(=O)NCC(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)NCC(=O)O

InChI=1/C134H229N37O36S/c1-25-73(16)109(168-104(179)64-144-117(190)84(38-28-32-47-135)157-126(199)94(55-69(8)9)164-123(196)90(46-51-208-24)159-129(202)97(58-99(141)174)166-122(195)86(40-30-34-49-137)158-128(201)96(57-81-59-142-83-37-27-26-36-82(81)83)165-127(200)93(54-68(6)7)161-111(184)74(17)139)132(205)147-63-103(178)154-85(39-29-33-48-136)121(194)163-92(53-67(4)5)125(198)152-75(18)112(185)143-62-102(177)155-89(42-44-98(140)173)120(193)153-78(21)113(186)151-79(22)115(188)162-91(52-66(2)3)119(192)145-60-100(175)150-77(20)116(189)169-108(72(14)15)133(206)160-87(41-31-35-50-138)124(197)171-110(80(23)172)134(207)167-95(56-70(10)11)130(203)170-107(71(12)13)131(204)146-61-101(176)149-76(19)114(187)156-88(43-45-105(180)181)118(191)148-65-106(182)183/h26-27,36-37,59,66-80,84-97,107-110,142,172H,25,28-35,38-58,60-65,135-139H2,1-24H3,(H2,140,173)(H2,141,174)(H,143,185)(H,144,190)(H,145,192)(H,146,204)(H,147,205)(H,148,191)(H,149,176)(H,150,175)(H,151,186)(H,152,198)(H,153,193)(H,154,178)(H,155,177)(H,156,187)(H,157,199)(H,158,201)(H,159,202)(H,160,206)(H,161,184)(H,162,188)(H,163,194)(H,164,196)(H,165,200)(H,166,195)(H,167,207)(H,168,179)(H,169,189)(H,170,203)(H,171,197)(H,180,181)(H,182,183)/t73-,74-,75-,76-,77-,78-,79-,80+,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,107-,108-,109-,110-/s2

InChIKey=RRYXYOGHBDRYAV-UXVUZBRKNA-N


Database reference: