BIOPEP-UWM: Report

ID 5373
Name dermaseptin B4
sequence
ALWKDILKNVGKAAGKAVLNTVTDMVNQG
Function:
Possesses a potent antimicrobial activity against gram-positive and gram-negative bacteria. Probably acts by disturbing membrane functions with its amphipathic structure
 
Number of residues
29
Activity code
ab
Activity :
antibacterial
Chemical mass 3055.5424 Monoisotopic mass 3053.6643
EC50 :
0.00 µM


Bibliographic data:
Authors
Charpentier S., Amiche M., Mester J., Vouille V., Le Caer J.-P., Nicolas P., Delfour A.;
Title
"Structure, synthesis, and molecular cloning of dermaseptins B, a family of skin peptide antibiotics.";J. Biol. Chem. 273:14690-14697.
Year Source
1998 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: N[C@@]([H])(C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2c1cccc2)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CC(=O)O)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(C(C)C)C(=O)NCC(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C)C(=O)NCC(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)N[C@@]([H])(CC(=O)O)C(=O)N[C@@]([H])(CCSC)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)NCC(=O)O

InChI=1/C135H228N38O40S/c1-24-69(16)107(171-128(206)93(57-101(184)185)162-118(196)82(40-30-34-47-139)155-123(201)88(52-76-58-145-78-36-26-25-35-77(76)78)159-121(199)85(49-62(2)3)158-110(188)70(17)140)133(211)164-86(50-63(4)5)120(198)154-81(39-29-33-46-138)117(195)160-90(54-96(143)178)126(204)168-103(65(8)9)129(207)147-60-99(181)153-79(37-27-31-44-136)115(193)150-72(19)112(190)149-71(18)111(189)146-59-98(180)152-80(38-28-32-45-137)116(194)151-73(20)113(191)167-104(66(10)11)130(208)163-87(51-64(6)7)122(200)161-91(55-97(144)179)127(205)172-109(75(22)175)135(213)170-106(68(14)15)132(210)173-108(74(21)174)134(212)166-92(56-100(182)183)125(203)157-84(43-48-214-23)119(197)169-105(67(12)13)131(209)165-89(53-95(142)177)124(202)156-83(41-42-94(141)176)114(192)148-61-102(186)187/h25-26,35-36,58,62-75,79-93,103-109,145,174-175H,24,27-34,37-57,59-61,136-140H2,1-23H3,(H2,141,176)(H2,142,177)(H2,143,178)(H2,144,179)(H,146,189)(H,147,207)(H,148,192)(H,149,190)(H,150,193)(H,151,194)(H,152,180)(H,153,181)(H,154,198)(H,155,201)(H,156,202)(H,157,203)(H,158,188)(H,159,199)(H,160,195)(H,161,200)(H,162,196)(H,163,208)(H,164,211)(H,165,209)(H,166,212)(H,167,191)(H,168,204)(H,169,197)(H,170,213)(H,171,206)(H,172,205)(H,173,210)(H,182,183)(H,184,185)(H,186,187)/t69-,70-,71-,72-,73-,74+,75+,79-,80-,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,103-,104-,105-,106-,107-,108-,109-/s2

InChIKey=FWLYUZXJCXQRHY-JWSXQPDZNA-N


Database reference: