BIOPEP-UWM: Report

ID 5374
Name dermaseptin B5
sequence
GLWNKIKEAASKAAGKAALGFVNEMVG
Function:
Possesses a potent antimicrobial activity against gram-positive and gram-negative bacteria. Probably acts by disturbing membrane functions with its amphipathic structure
 
Number of residues
27
Activity code
ab
Activity :
antibacterial
Chemical mass 2761.1955 Monoisotopic mass 2759.4746
EC50 :
0.00 µM


Bibliographic data:
Authors
Charpentier S., Amiche M., Mester J., Vouille V., Le Caer J.-P., Nicolas P., Delfour A.;
Title
"Structure, synthesis, and molecular cloning of dermaseptins B, a family of skin peptide antibiotics."; J. Biol. Chem. 273:14690-14697.
Year Source
1998 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: NCC(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2c1cccc2)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C)C(=O)NCC(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CC(C)C)C(=O)NCC(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)N[C@@]([H])(CCSC)C(=O)N[C@@]([H])(C(C)C)C(=O)NCC(=O)O

InChI=1/C124H202N34O35S/c1-18-66(10)101(158-114(183)80(39-27-31-48-128)145-118(187)88(54-91(130)160)153-117(186)87(53-74-57-132-76-35-23-22-34-75(74)76)152-116(185)85(51-63(4)5)143-93(162)56-129)124(193)150-79(38-26-30-47-127)112(181)147-81(40-42-96(165)166)111(180)141-70(14)105(174)138-72(16)107(176)155-90(61-159)121(190)146-78(37-25-29-46-126)110(179)140-68(12)103(172)136-67(11)102(171)133-58-94(163)142-77(36-24-28-45-125)109(178)139-69(13)104(173)137-71(15)106(175)151-84(50-62(2)3)108(177)134-59-95(164)144-86(52-73-32-20-19-21-33-73)120(189)157-100(65(8)9)123(192)154-89(55-92(131)161)119(188)148-82(41-43-97(167)168)113(182)149-83(44-49-194-17)115(184)156-99(64(6)7)122(191)135-60-98(169)170/h19-23,32-35,57,62-72,77-90,99-101,132,159H,18,24-31,36-56,58-61,125-129H2,1-17H3,(H2,130,160)(H2,131,161)(H,133,171)(H,134,177)(H,135,191)(H,136,172)(H,137,173)(H,138,174)(H,139,178)(H,140,179)(H,141,180)(H,142,163)(H,143,162)(H,144,164)(H,145,187)(H,146,190)(H,147,181)(H,148,188)(H,149,182)(H,150,193)(H,151,175)(H,152,185)(H,153,186)(H,154,192)(H,155,176)(H,156,184)(H,157,189)(H,158,183)(H,165,166)(H,167,168)(H,169,170)/t66-,67-,68-,69-,70-,71-,72-,77-,78-,79-,80-,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,99-,100-,101-/s2

InChIKey=YYJOOSJAXCEJLI-UFDCJQHONA-N


Database reference: