BIOPEP-UWM: Report

ID 5379
Name Brevinin-1EA
sequence
FLPAIFRMAAKVVPTIICSITKKC
Function:
Shows antibacterial activity against representative gram-negative and gram-positive bacterial species, and a very high hemolytic activity.
 
Number of residues
24
Activity code
ab
Activity :
antibacterial
Chemical mass 2651.3418 Monoisotopic mass 2649.4889
EC50 :
0.00 µM


Bibliographic data:
Authors
Simmaco M., Mignogna G., Barra D., Bossa F.;
Title
"Antimicrobial peptides from skin secretions of Rana esculenta. Molecular cloning of cDNAs encoding esculentin and brevinins and isolation of new active peptides."; J. Biol. Chem. 269:11956-11961.
Year Source
1994 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CCSC)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(C(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(CS)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CS)C(=O)O
InChI=1/C123H208N30O28S3/c1-21-67(11)93(146-101(159)73(17)133-111(169)89-48-38-55-152(89)120(178)85(58-64(5)6)140-102(160)78(127)59-76-40-27-25-28-41-76)114(172)139-84(60-77-42-29-26-30-43-77)108(166)136-82(47-37-54-130-123(128)129)105(163)137-83(50-57-184-20)103(161)132-71(15)99(157)131-72(16)100(158)134-81(46-33-36-53-126)107(165)144-91(65(7)8)113(171)145-92(66(9)10)121(179)153-56-39-49-90(153)112(170)150-98(75(19)156)119(177)149-96(70(14)24-4)116(174)148-94(68(12)22-2)115(173)142-87(62-182)110(168)141-86(61-154)109(167)147-95(69(13)23-3)117(175)151-97(74(18)155)118(176)138-80(45-32-35-52-125)104(162)135-79(44-31-34-51-124)106(164)143-88(63-183)122(180)181/h25-30,40-43,64-75,78-98,154-156,182-183H,21-24,31-39,44-63,124-127H2,1-20H3,(H,131,157)(H,132,161)(H,133,169)(H,134,158)(H,135,162)(H,136,166)(H,137,163)(H,138,176)(H,139,172)(H,140,160)(H,141,168)(H,142,173)(H,143,164)(H,144,165)(H,145,171)(H,146,159)(H,147,167)(H,148,174)(H,149,177)(H,150,170)(H,151,175)(H,180,181)(H4,128,129,130)/t67-,68-,69-,70-,71-,72-,73-,74+,75+,78-,79-,80-,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-/s2

InChIKey=DRPSGKLWKWEWQL-YSIJAYPGNA-N

From Rana esculenta (Edible frog).
Disulfide band: 18-24

Quoted in: Amiche M., Seon A. A., Pierre T. R., Nicolas P., The dermaseptin precursor : a protein family with a common preproregion and a variable C-terminal antimicrobial domain. FEBS Letters 456(1999) 352-356.


Database reference:
SWISS-PROT: BR1A_RANES