BIOPEP-UWM: Report

ID 5380
Name Brevinin-1EB
sequence
VIPFVASVAAEMQHVYCAASRKC
Function:
Shows antibacterial activity against representative gram-negative and gram-positive bacterial species, and a very high hemolytic activity.
 
Number of residues
23
Activity code
ab
Activity :
antibacterial
Chemical mass 2480.9222 Monoisotopic mass 2479.2135
EC50 :
0.00 µM


Bibliographic data:
Authors
Simmaco M., Mignogna G., Barra D., Bossa F.;
Title
"Antimicrobial peptides from skin secretions of Rana esculenta. Molecular cloning of cDNAs encoding esculentin and brevinins and isolation of new active peptides."; J. Biol. Chem. 269:11956-11961.
Year Source
1994 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)N[C@@]([H])(CCSC)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(CS)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CS)C(=O)O

InChI=1/C109H174N30O30S3/c1-17-56(10)85(138-103(163)81(112)52(2)3)107(167)139-41-24-29-78(139)102(162)129-72(43-62-25-19-18-20-26-62)97(157)135-82(53(4)5)104(164)122-61(15)90(150)132-75(48-141)100(160)137-83(54(6)7)105(165)121-58(12)87(147)118-59(13)88(148)123-69(35-37-80(144)145)93(153)127-70(38-42-172-16)95(155)126-68(34-36-79(111)143)94(154)128-73(45-64-46-115-51-117-64)98(158)136-84(55(8)9)106(166)130-71(44-63-30-32-65(142)33-31-63)96(156)133-76(49-170)101(161)120-57(11)86(146)119-60(14)89(149)131-74(47-140)99(159)125-67(28-23-40-116-109(113)114)91(151)124-66(27-21-22-39-110)92(152)134-77(50-171)108(168)169/h18-20,25-26,30-33,46,51-61,66-78,81-85,140-142,170-171H,17,21-24,27-29,34-45,47-50,110,112H2,1-16H3,(H2,111,143)(H,115,117)(H,118,147)(H,119,146)(H,120,161)(H,121,165)(H,122,164)(H,123,148)(H,124,151)(H,125,159)(H,126,155)(H,127,153)(H,128,154)(H,129,162)(H,130,166)(H,131,149)(H,132,150)(H,133,156)(H,134,152)(H,135,157)(H,136,158)(H,137,160)(H,138,163)(H,144,145)(H,168,169)(H4,113,114,116)/t56-,57-,58-,59-,60-,61-,66-,67-,68-,69-,70-,71-,72-,73-,74-,75-,76-,77-,78-,81-,82-,83-,84-,85-/s2

InChIKey=YFPRKYYTKGLAPW-NKLHIACKNA-N


From Rana esculenta (Edible frog).
Disulfide bond: 17-23

quoted in : Strub J-M, Hubert P., Nullans G., Aunis D., Metz-Boutigue M-H. Antibacterial activity of secretolytin, a chromogranin B-derived peptide (614-626), is correlated with peptide structure. FEBS Letters 379, (1996), 273-278.SWISS-PROT: BR1B_RANES


Database reference: