BIOPEP-UWM: Report

ID 5382
Name Brevinin-2EB
sequence
GILDTLKNLAKTAGKGALQGLVKMASCKLSGQC
Function:
Shows antibacterial activity against representative gram-negative and gram-positive bacterial species, and hemolytic activity.
 
Number of residues
33
Activity code
ab
Activity :
antibacterial
Chemical mass 3318.9653 Monoisotopic mass 3316.7975
EC50 :
0.00 µM


Bibliographic data:
Authors
Simmaco M., Mignogna G., Barra D., Bossa F.;
Title
"Antimicrobial peptides from skin secretions of Rana esculenta. Molecular cloning of cDNAs encoding esculentin and brevinins and isolation of new active peptides."; J. Biol. Chem. 269:11956-11961.
Year Source
1994 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: NCC(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CC(=O)O)C(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)N[C@@]([H])(C)C(=O)NCC(=O)N[C@@]([H])(CCCCN)C(=O)NCC(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)NCC(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CCSC)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CS)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CO)C(=O)NCC(=O)N[C@@]([H])(CCC(=O)N)C(=O)N[C@@]([H])(CS)C(=O)O

InChI=1/C142H253N41O43S3/c1-24-75(16)112(180-105(191)59-148)139(222)174-95(56-73(12)13)131(214)173-97(58-110(196)197)135(218)183-114(81(22)187)141(224)175-94(55-72(10)11)130(213)164-83(36-26-31-46-144)125(208)172-96(57-104(151)190)133(216)171-91(52-69(4)5)128(211)158-78(19)117(200)163-86(39-29-34-49-147)127(210)182-113(80(21)186)140(223)159-76(17)115(198)152-61-107(193)160-82(35-25-30-45-143)119(202)153-60-106(192)156-77(18)116(199)169-92(53-70(6)7)129(212)166-87(40-42-102(149)188)120(203)154-63-109(195)162-90(51-68(2)3)134(217)181-111(74(14)15)138(221)168-85(38-28-33-48-146)123(206)167-89(44-50-229-23)122(205)157-79(20)118(201)176-99(65-185)136(219)178-100(66-227)137(220)165-84(37-27-32-47-145)124(207)170-93(54-71(8)9)132(215)177-98(64-184)121(204)155-62-108(194)161-88(41-43-103(150)189)126(209)179-101(67-228)142(225)226/h68-101,111-114,184-187,227-228H,24-67,143-148H2,1-23H3,(H2,149,188)(H2,150,189)(H2,151,190)(H,152,198)(H,153,202)(H,154,203)(H,155,204)(H,156,192)(H,157,205)(H,158,211)(H,159,223)(H,160,193)(H,161,194)(H,162,195)(H,163,200)(H,164,213)(H,165,220)(H,166,212)(H,167,206)(H,168,221)(H,169,199)(H,170,207)(H,171,216)(H,172,208)(H,173,214)(H,174,222)(H,175,224)(H,176,201)(H,177,215)(H,178,219)(H,179,209)(H,180,191)(H,181,217)(H,182,210)(H,183,218)(H,196,197)(H,225,226)/t75-,76-,77-,78-,79-,80+,81+,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,111-,112-,113-,114-/s2

InChIKey=MUUBAJRFJBQPNF-FDUIRRAHNA-N


From Rana esculenta (Edible frog).
Disulfide bond: 27-33

Quoted in: Amiche M., Seon A. A., Pierre T. R., Nicolas P., The dermaseptin precursor : a protein family with a common preproregion and a variable C-terminal antimicrobial domain. FEBS Letters 456(1999) 352-356.


Database reference:
SWISS-PROT: BR2B_RANES