BIOPEP-UWM: Report

ID 5390
Name dermaseptin B6
sequence
ALWKDILKNAGKAALNEINQLVNQG
Function:
Possesses a potent antimicrobial activity against gram-positive and gram-negative bacteria. Probably acts by disturbing membrane functions with its amphipathic structure.
 
Number of residues
25
Activity code
ab
Activity :
antibacterial
Chemical mass 2722.0955 Monoisotopic mass 2720.4927
EC50 :
0.00 µM


Bibliographic data:
Authors
Charpentier S., Amiche M., Mester J., Vouille V., Le Caer J.-P., Nicolas P., Delfour A.;
Title
"Structure, synthesis, and molecular cloning of dermaseptins B, a family of skin peptide antibiotics."; J. Biol. Chem. 273:14690-14697.
Year Source
1998 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: N[C@@]([H])(C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2c1cccc2)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CC(=O)O)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(C)C(=O)NCC(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)NCC(=O)O


InChI=1S/C121H201N35O36/c1-19-61(13)97(121(192)153-84(51-91(131)162)116(187)142-74(35-38-87(127)158)107(178)146-79(46-59(9)10)117(188)154-96(60(11)12)119(190)152-83(50-90(130)161)115(186)141-73(34-37-86(126)157)103(174)134-55-95(168)169)155-108(179)75(36-39-93(164)165)143-114(185)82(49-89(129)160)149-112(183)77(44-57(5)6)145-102(173)66(18)135-101(172)65(17)137-104(175)70(31-23-26-40-122)138-92(163)54-133-100(171)64(16)136-109(180)81(48-88(128)159)148-105(176)71(32-24-27-41-123)139-110(181)78(45-58(7)8)151-120(191)98(62(14)20-2)156-118(189)85(52-94(166)167)150-106(177)72(33-25-28-42-124)140-113(184)80(47-67-53-132-69-30-22-21-29-68(67)69)147-111(182)76(43-56(3)4)144-99(170)63(15)125/h21-22,29-30,53,56-66,70-85,96-98,132H,19-20,23-28,31-52,54-55,122-125H2,1-18H3,(H2,126,157)(H2,127,158)(H2,128,159)(H2,129,160)(H2,130,161)(H2,131,162)(H,133,171)(H,134,174)(H,135,172)(H,136,180)(H,137,175)(H,138,163)(H,139,181)(H,140,184)(H,141,186)(H,142,187)(H,143,185)(H,144,170)(H,145,173)(H,146,178)(H,147,182)(H,148,176)(H,149,183)(H,150,177)(H,151,191)(H,152,190)(H,153,192)(H,154,188)(H,155,179)(H,156,189)(H,164,165)(H,166,167)(H,168,169)/t61-,62-,63-,64-,65-,66-,70-,71-,72-,73-,74-,75-,76-,77-,78-,79-,80-,81-,82-,83-,84-,85-,96-,97-,98-/m0/s1


InChIKey: JQELTHREKYRANU-LRLJCZQGSA-N



From Phyllomedusa bicolor (Two-colored leaf frog).
Amidated C-terminus.


Database reference: