BIOPEP-UWM: Report

ID 5393
Name rugosin B
sequence
SLFSLIKAGAKFLGKNLLKQGAQYAACKVSKECG
Function:
Shows antibacterial activity against both gram-negative and gram-positive bacteria.
 
Number of residues
34
Activity code
ab
Activity :
antibacterial
Chemical mass 3573.2259 Monoisotopic mass 3570.9357
EC50 :
0.00 µM


Bibliographic data:
Authors
Suzuki S., Ohe Y., Kagegawa T., Tatemoto K.;
Title
"Isolation and characterization of novel antimicrobial peptides, rugosins A, B and C, from the skin of the frog, Rana rugosa."; Biochem. Biophys. Res. Commun. 212:249-254.
Year Source
1995 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: N[C@@]([H])(CO)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(C)C(=O)NCC(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(CC(C)C)C(=O)NCC(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)NCC(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CS)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)N[C@@]([H])(CS)C(=O)NCC(=O)O


InChI=1S/C161H267N43O44S2/c1-20-89(14)131(204-156(243)113(69-87(10)11)194-158(245)118(79-206)199-154(241)116(71-96-41-25-22-26-42-96)197-151(238)110(66-84(4)5)190-137(224)99(168)78-205)161(248)189-101(44-28-34-60-163)141(228)179-90(15)132(219)172-74-125(212)176-91(16)134(221)182-102(45-29-35-61-164)145(232)196-115(70-95-39-23-21-24-40-95)153(240)191-109(65-83(2)3)139(226)174-76-127(214)181-100(43-27-33-59-162)142(229)198-117(73-124(171)211)155(242)193-112(68-86(8)9)152(239)192-111(67-85(6)7)150(237)184-103(46-30-36-62-165)143(230)187-106(53-56-122(169)209)138(225)173-75-126(213)177-92(17)135(222)183-107(54-57-123(170)210)146(233)195-114(72-97-49-51-98(208)52-50-97)149(236)180-93(18)133(220)178-94(19)136(223)201-121(82-250)159(246)186-105(48-32-38-64-167)148(235)203-130(88(12)13)160(247)200-119(80-207)157(244)185-104(47-31-37-63-166)144(231)188-108(55-58-128(215)216)147(234)202-120(81-249)140(227)175-77-129(217)218/h21-26,39-42,49-52,83-94,99-121,130-131,205-208,249-250H,20,27-38,43-48,53-82,162-168H2,1-19H3,(H2,169,209)(H2,170,210)(H2,171,211)(H,172,219)(H,173,225)(H,174,226)(H,175,227)(H,176,212)(H,177,213)(H,178,220)(H,179,228)(H,180,236)(H,181,214)(H,182,221)(H,183,222)(H,184,237)(H,185,244)(H,186,246)(H,187,230)(H,188,231)(H,189,248)(H,190,224)(H,191,240)(H,192,239)(H,193,242)(H,194,245)(H,195,233)(H,196,232)(H,197,238)(H,198,229)(H,199,241)(H,200,247)(H,201,223)(H,202,234)(H,203,235)(H,204,243)(H,215,216)(H,217,218)/t89-,90-,91-,92-,93-,94-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,130-,131-/m0/s1


InChIKey: YBBGSNBTWRGYHC-LDENTCCLSA-N

From Rana rugosa (Wrinkled frog).
Amidated C-terminus.
Disulfid: 27-33


Database reference:
SWISS-PROT RUGB_RANRU