BIOPEP-UWM: Report

ID 5426
Name Ligatoxin A
sequence
KSCCPSTTARNIYNTCRLTGTSRPTCASLSGCKIISGSTCDSGWNH
Function:
Thionins are small plant proteins which are toxic to animal cells. They seem to exert their toxic effect at the level of the cell membrane. The precise function, in plants, of these proteins is not known.
 
Number of residues
46
Activity code
ab
Activity :
antibacterial
Chemical mass 4840.4110 Monoisotopic mass 4837.1849
EC50 :
0.00 µM


Bibliographic data:
Authors
Thunberg E., Samuelsson G.
Title
The amino acid sequence of ligatoxin A from the mistletoe Phoradendron liga. Acta Pharmaceutica Suecica, 19, 447-456, 1982
Year Source
1982 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CS)C(=O)N[C@@]([H])(CS)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)N[C@@]([H])(CS)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)NCC(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)N[C@@]([H])(CS)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CO)C(=O)NCC(=O)N[C@@]([H])(CS)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(CO)C(=O)NCC(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)N[C@@]([H])(CS)C(=O)N[C@@]([H])(CC(=O)O)C(=O)N[C@@]([H])(CO)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2c1cccc2)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)O

InChI=1S/C196H321N63O68S6/c1-20-86(8)142(250-167(300)114(60-135(201)277)230-158(291)106(38-29-49-210-194(203)204)224-152(285)90(12)220-185(318)147(93(15)270)257-190(323)151(97(19)274)255-173(306)125(76-267)240-179(312)132-41-32-53-259(132)192(325)131(82-333)247-178(311)128(79-330)243-171(304)123(74-265)237-154(287)103(199)35-25-27-47-197)182(315)234-111(56-98-43-45-101(275)46-44-98)162(295)232-115(61-136(202)278)168(301)253-148(94(16)271)187(320)245-129(80-331)176(309)226-107(39-30-50-211-195(205)206)159(292)228-110(55-85(6)7)166(299)252-145(91(13)268)181(314)217-68-140(282)248-146(92(14)269)186(319)242-124(75-266)169(302)227-108(40-31-51-212-196(207)208)191(324)258-52-33-42-133(258)180(313)256-150(96(18)273)189(322)244-127(78-329)174(307)219-89(11)153(286)236-122(73-264)170(303)229-109(54-84(4)5)161(294)238-118(69-260)155(288)216-67-139(281)223-126(77-328)175(308)225-105(37-26-28-48-198)160(293)249-144(88(10)22-3)184(317)251-143(87(9)21-2)183(316)241-120(71-262)157(290)215-66-138(280)222-121(72-263)172(305)254-149(95(17)272)188(321)246-130(81-332)177(310)233-116(62-141(283)284)165(298)239-119(70-261)156(289)214-65-137(279)221-112(57-99-63-213-104-36-24-23-34-102(99)104)163(296)231-113(59-134(200)276)164(297)235-117(193(326)327)58-100-64-209-83-218-100/h23-24,34,36,43-46,63-64,83-97,103,105-133,142-151,213,260-275,328-333H,20-22,25-33,35,37-42,47-62,65-82,197-199H2,1-19H3,(H2,200,276)(H2,201,277)(H2,202,278)(H,209,218)(H,214,289)(H,215,290)(H,216,288)(H,217,314)(H,219,307)(H,220,318)(H,221,279)(H,222,280)(H,223,281)(H,224,285)(H,225,308)(H,226,309)(H,227,302)(H,228,292)(H,229,303)(H,230,291)(H,231,296)(H,232,295)(H,233,310)(H,234,315)(H,235,297)(H,236,286)(H,237,287)(H,238,294)(H,239,298)(H,240,312)(H,241,316)(H,242,319)(H,243,304)(H,244,322)(H,245,320)(H,246,321)(H,247,311)(H,248,282)(H,249,293)(H,250,300)(H,251,317)(H,252,299)(H,253,301)(H,254,305)(H,255,306)(H,256,313)(H,257,323)(H,283,284)(H,326,327)(H4,203,204,210)(H4,205,206,211)(H4,207,208,212)/t86-,87-,88-,89-,90-,91+,92+,93+,94+,95+,96+,97+,103-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,142-,143-,144-,145-,146-,147-,148-,149-,150-,151-/m0/s1

InChIKey=HHBCACZFGVLOBQ-VHZZSMCISA-N


From Phoradendron liga (Argentine mistletoe)
Disulfid: 3-40; 4-32; 16-26


Database reference:
EROP-Moscow: ID E04113

UniProt: ID P01540 (THNA_PHOLI)