BIOPEP-UWM: Report

ID 5427
Name Viscotoxin 1-PS
sequence
KSCCPNTTGRNIYNTCRFGGGSREVCARISGCKIISASTCPSDYPK
Function:
Thionins are small plant proteins which are toxic to animal cells. They seem to exert their toxic effect at the level of the cell membrane. The precise function, in plants, of these proteins is not known.
 
Number of residues
46
Activity code
ab
Activity :
antibacterial
Chemical mass 4903.5542 Monoisotopic mass 4900.2684
EC50 :
0.00 µM


Bibliographic data:
Authors
Samuelsson G., Jayawardene A. L.
Title
Isolation and characterization of viscotoxin 1-Ps from Viscum album L. ssp. austriacum (Wiesb.) vollman, growing on Pinus silvestris. Acta Pharmaceut. Suecica, 11, 175-184, 1974
Year Source
1974 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CS)C(=O)N[C@@]([H])(CS)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)NCC(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)N[C@@]([H])(CS)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)NCC(=O)NCC(=O)NCC(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CS)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(CO)C(=O)NCC(=O)N[C@@]([H])(CS)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)N[C@@]([H])(CS)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CC(=O)O)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CCCCN)C(=O)O

InChI=1S/C202H330N64O66S6/c1-17-94(7)150(258-171(304)119(72-139(207)279)239-163(296)110(42-30-62-218-199(210)211)229-145(285)80-226-186(319)154(100(13)273)263-194(327)157(103(16)276)261-173(306)121(74-141(209)281)242-184(317)137-47-35-67-265(137)196(329)134(91-337)253-182(315)132(89-335)250-177(310)127(84-270)246-160(293)109(206)39-24-27-59-203)188(321)243-118(70-105-49-53-107(277)54-50-105)169(302)240-120(73-140(208)280)172(305)260-155(101(14)274)192(325)252-133(90-336)181(314)235-113(44-32-64-220-201(214)215)165(298)238-117(69-104-37-22-21-23-38-104)161(294)224-77-143(283)222-76-142(282)223-78-144(284)230-125(82-268)175(308)233-112(43-31-63-219-200(212)213)164(297)236-115(57-58-147(287)288)168(301)255-149(93(5)6)187(320)251-131(88-334)179(312)228-98(11)158(291)232-114(45-33-65-221-202(216)217)167(300)256-151(95(8)18-2)189(322)248-124(81-267)162(295)225-79-146(286)231-130(87-333)180(313)234-111(40-25-28-60-204)166(299)257-153(97(10)20-4)191(324)259-152(96(9)19-3)190(323)249-126(83-269)174(307)227-99(12)159(292)245-129(86-272)178(311)262-156(102(15)275)193(326)254-135(92-338)197(330)266-68-36-48-138(266)185(318)247-128(85-271)176(309)241-122(75-148(289)290)170(303)244-123(71-106-51-55-108(278)56-52-106)195(328)264-66-34-46-136(264)183(316)237-116(198(331)332)41-26-29-61-205/h21-23,37-38,49-56,93-103,109-138,149-157,267-278,333-338H,17-20,24-36,39-48,57-92,203-206H2,1-16H3,(H2,207,279)(H2,208,280)(H2,209,281)(H,222,283)(H,223,282)(H,224,294)(H,225,295)(H,226,319)(H,227,307)(H,228,312)(H,229,285)(H,230,284)(H,231,286)(H,232,291)(H,233,308)(H,234,313)(H,235,314)(H,236,297)(H,237,316)(H,238,298)(H,239,296)(H,240,302)(H,241,309)(H,242,317)(H,243,321)(H,244,303)(H,245,292)(H,246,293)(H,247,318)(H,248,322)(H,249,323)(H,250,310)(H,251,320)(H,252,325)(H,253,315)(H,254,326)(H,255,301)(H,256,300)(H,257,299)(H,258,304)(H,259,324)(H,260,305)(H,261,306)(H,262,311)(H,263,327)(H,287,288)(H,289,290)(H,331,332)(H4,210,211,218)(H4,212,213,219)(H4,214,215,220)(H4,216,217,221)/t94-,95-,96-,97-,98-,99-,100+,101+,102+,103+,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,149-,150-,151-,152-,153-,154-,155-,156-,157-/m0/s1

InChIKey=QMOWLRWYAFIDQC-IBYJQKFISA-N


From Viscum album (European mistletoe).
Ddisulfide bonds: 3-40; 4-32; 16-26


Database reference:
EROP-Moscow: ID E04107

UniProt: ID P01537 (THN1_VISAL)