BIOPEP-UWM: Report
| ID | 5455 |
| Name | aurein 1.2 |
| sequence |
| Function: | |||
| Peptide derived from the secretion of the granular dorsal glands of the Green and Golden Bell Frog Litoria aurea. Peptides isolated from amphibians show wide-spectrum antibiotic and anticancer activity. Antimicrobial activity against L.lactis, M.luteus, P.multocida, S.aureus, S.epidermidis and S.uberis. Probably acts by disturbing membrane functions with its amphipathic structure. Shows anticancer activity. Active against: Gram+ & Gram-, fungi, cancer cells | |||
| Number of residues | 13 |
Activity code | ac |
| Activity : | anticancer |
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| Chemical mass | 1480.7415 | Monoisotopic mass | 1479.8310 | |
| EC50 : | 0.00 µM |
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| Bibliographic data: | |
| Authors | |
| Rozek T., Wegener K.L., Bowie J.H., Olver I.N., Carver J.A., Wallace J.C., Tyler M.J.; | |
| Title | |
| "The antibiotic and anticancer active aurein peptides from the australian bell frogs Litoria aurea and Litoria raniformis the solution structure of aurein 1.2."; Eur. J. Biochem. 267:5330-5341. | |
| Year | Source |
| 2000 | Journal |
| Additional information: |
| From Litoria raniformis (Southern bell frog). database ID: AP00013, http://aps.unmc.edu/AP/database |
| Database reference: |
| SWISS-PROT AU12_LITRA |