BIOPEP-UWM: Report

ID 5470
Name beta-defensin 7
sequence
QGVRNFVTCRINRGFCVPIRCPGHRRQIGTCLGPRIKCCR
Function:
Has bactericidal activity. Active against E.coli ML35 and S.aureus 502A.
 
Number of residues
40
Activity code
ab
Activity :
antibacterial
Chemical mass 4572.4660 Monoisotopic mass 4569.3480
EC50 :
0.00 µM


Bibliographic data:
Authors
Selsted M.E., Tang Y.-Q., Morris W.L., McGuire P.A., Novotny M.J., Smith W., Henschen A.H., Cullor J.S.;
Title
"Purification, primary structures, and antibacterial activities of beta-defensins, a new family of antimicrobial peptides from bovine neutrophils."; J. Biol. Chem. 268:6641-6648.
Year Source
1993 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: N[C@@]([H])(CCC(=O)N)C(=O)NCC(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)N[C@@]([H])(CS)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)NCC(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(CS)C(=O)N[C@@]([H])(C(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CS)C(=O)N1[C@@]([H])(CCC1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)NCC(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)N[C@@]([H])(CS)C(=O)N[C@@]([H])(CC(C)C)C(=O)NCC(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CS)C(=O)N[C@@]([H])(CS)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)O


InChI=1S/C192H325N71O47S6/c1-19-97(13)144(174(299)227-84-139(273)253-148(101(17)264)180(305)249-126(89-314)168(293)242-117(74-93(5)6)152(277)228-85-140(274)261-71-39-56-130(261)172(297)237-114(53-37-69-222-191(211)212)159(284)257-145(98(14)20-2)177(302)239-108(46-29-30-62-193)156(281)246-124(87-312)169(294)248-123(86-311)167(292)241-116(184(309)310)54-38-70-223-192(213)214)256-160(285)115(59-61-133(196)267)236-154(279)109(48-32-64-217-186(201)202)233-153(278)110(49-33-65-218-187(203)204)234-162(287)120(77-105-80-215-92-229-105)231-137(271)82-226-171(296)129-55-40-72-262(129)182(307)128(91-316)251-157(282)112(51-35-67-220-189(207)208)240-178(303)147(100(16)22-4)259-173(298)131-57-41-73-263(131)183(308)143(96(11)12)255-170(295)127(90-315)247-161(286)118(75-103-42-25-23-26-43-103)230-136(270)81-225-151(276)107(47-31-63-216-185(199)200)232-163(288)122(79-135(198)269)245-179(304)146(99(15)21-3)258-158(283)113(52-36-68-221-190(209)210)235-166(291)125(88-313)250-181(306)149(102(18)265)260-176(301)142(95(9)10)254-165(290)119(76-104-44-27-24-28-45-104)243-164(289)121(78-134(197)268)244-155(280)111(50-34-66-219-188(205)206)238-175(300)141(94(7)8)252-138(272)83-224-150(275)106(194)58-60-132(195)266/h23-28,42-45,80,92-102,106-131,141-149,264-265,311-316H,19-22,29-41,46-79,81-91,193-194H2,1-18H3,(H2,195,266)(H2,196,267)(H2,197,268)(H2,198,269)(H,215,229)(H,224,275)(H,225,276)(H,226,296)(H,227,299)(H,228,277)(H,230,270)(H,231,271)(H,232,288)(H,233,278)(H,234,287)(H,235,291)(H,236,279)(H,237,297)(H,238,300)(H,239,302)(H,240,303)(H,241,292)(H,242,293)(H,243,289)(H,244,280)(H,245,304)(H,246,281)(H,247,286)(H,248,294)(H,249,305)(H,250,306)(H,251,282)(H,252,272)(H,253,273)(H,254,290)(H,255,295)(H,256,285)(H,257,284)(H,258,283)(H,259,298)(H,260,301)(H,309,310)(H4,199,200,216)(H4,201,202,217)(H4,203,204,218)(H4,205,206,219)(H4,207,208,220)(H4,209,210,221)(H4,211,212,222)(H4,213,214,223)/t97-,98-,99-,100-,101+,102+,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,141-,142-,143-,144-,145-,146-,147-,148-,149-/m0/s1


InChIKey: ZKJNLCRCEVWZDV-BSPYTXKVSA-N


From Bos taurus (Bovine) .
Disulfid: 9-38; 16-31; 21-39


Database reference:
SWISS-PROT BD07_BOVIN