BIOPEP-UWM: Report

ID 5473
Name aurein 3.1
sequence
GLFDIVKKIAGHIAGSIG
Function:
AUREIN 3.1 HAS ANTIMICROBIAL ACTIVITY AGAINST L.LACTIS, L.INNOCUA, M.LUTEUS, S.AUREUS, S.EPIDERMIDIS AND S.UBERIS. PROBABLY ACTS BY DISTURBING MEMBRANE FUNCTIONS WITH ITS AMPHIPATHIC STRUCTURE. AUREIN 3.1 SHOWS ANTICANCER ACTIVITY
 
Number of residues
18
Activity code
ab
Activity :
antibacterial
Chemical mass 1796.1125 Monoisotopic mass 1795.0324
EC50 :
0.00 µM


Bibliographic data:
Authors
Rozek T., Wegener K.L., Bowie J.H., Olver I.N., Carver J.A., Wallace J.C., Tyler M.J.;
Title
"The antibiotic and anticancer active aurein peptides from the australian bell frogs Litoria aurea and Litoria raniformis the solution structure of aurein 1.2."; Eur. J. Biochem. 267:5330-5341.
Year Source
2000 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides


InChI=1S/C83H138N22O22/c1-15-45(9)66(79(123)90-40-64(112)113)102-78(122)59(41-106)96-62(109)39-89-71(115)50(14)93-82(126)68(47(11)17-3)104-76(120)57(34-52-37-87-42-91-52)95-61(108)38-88-70(114)49(13)92-81(125)67(46(10)16-2)103-73(117)54(29-23-25-31-85)97-72(116)53(28-22-24-30-84)98-80(124)65(44(7)8)101-83(127)69(48(12)18-4)105-77(121)58(35-63(110)111)100-75(119)56(33-51-26-20-19-21-27-51)99-74(118)55(32-43(5)6)94-60(107)36-86/h19-21,26-27,37,42-50,53-59,65-69,106H,15-18,22-25,28-36,38-41,84-86H2,1-14H3,(H,87,91)(H,88,114)(H,89,115)(H,90,123)(H,92,125)(H,93,126)(H,94,107)(H,95,108)(H,96,109)(H,97,116)(H,98,124)(H,99,118)(H,100,119)(H,101,127)(H,102,122)(H,103,117)(H,104,120)(H,105,121)(H,110,111)(H,112,113)/t45-,46-,47-,48-,49-,50-,53-,54-,55-,56-,57-,58-,59-,65-,66-,67-,68-,69-/m0/s1


InChIKey: WVVFKEYCMJMQEA-FIWHZOERSA-N


From Litoria raniformis (Southern bell frog), Litoria aurea (Green and golden bell frog).
Amidated C-terminus.


Database reference:
SWISS-PROT AU31_LITRA