BIOPEP-UWM: Report

ID 5474
Name aurein 3.1.1
sequence
GLFDIVKKIAGHIA
Function:
Antimicrobial activity against L.lactis, M.luteus, P.multocida, S.aureus, S.epidermidis and S.uberis. Probably acts by disturbing membrane functions with its amphipathic structure. Shows anticancer activity.
 
Number of residues
14
Activity code
ab
Activity :
antibacterial
Chemical mass 1481.7758 Monoisotopic mass 1480.8739
EC50 :
0.00 µM


Bibliographic data:
Authors
Rozek T., Wegener K.L., Bowie J.H., Olver I.N., Carver J.A., Wallace J.C., Tyler M.J.;
Title
"The antibiotic and anticancer active aurein peptides from the australian bell frogs Litoria aurea and Litoria raniformis the solution structure of aurein 1.2."; Eur. J. Biochem. 267:5330-5341.
Year Source
2000 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: NCC(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(CC(=O)O)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(C)C(=O)O


InChI=1S/C70H116N18O17/c1-13-39(8)56(67(101)77-42(11)59(93)75-35-53(90)80-50(31-45-34-74-36-76-45)64(98)87-57(40(9)14-2)68(102)78-43(12)70(104)105)86-61(95)47(26-20-22-28-72)81-60(94)46(25-19-21-27-71)82-66(100)55(38(6)7)85-69(103)58(41(10)15-3)88-65(99)51(32-54(91)92)84-63(97)49(30-44-23-17-16-18-24-44)83-62(96)48(29-37(4)5)79-52(89)33-73/h16-18,23-24,34,36-43,46-51,55-58H,13-15,19-22,25-33,35,71-73H2,1-12H3,(H,74,76)(H,75,93)(H,77,101)(H,78,102)(H,79,89)(H,80,90)(H,81,94)(H,82,100)(H,83,96)(H,84,97)(H,85,103)(H,86,95)(H,87,98)(H,88,99)(H,91,92)(H,104,105)/t39-,40-,41-,42-,43-,46-,47-,48-,49-,50-,51-,55-,56-,57-,58-/m0/s1


InChIKey: FIMIVQFZGBEBHU-CPMIMXFSSA-N


From Litoria raniformis (Southern bell frog), Litoria aurea (Green and golden bell frog).


Database reference:
SWISS-PROT AU31_LITRA