BIOPEP-UWM: Report

ID 5479
Name beta-defensin 2
sequence
VRNHVTCRINRGFCVPIRCPGRTRQIGTCFGPRIKCCRSW
Function:
Has bactericidal activity. Active against E.coli ML35 and S.aureus 502A.
 
Number of residues
40
Activity code
ab
Activity :
antibacterial
Chemical mass 4648.5189 Monoisotopic mass 4645.3429
EC50 :
0.00 µM


Bibliographic data:
Authors
Selsted M.E., Tang Y.-Q., Morris W.L., McGuire P.A., Novotny M.J., Smith W., Henschen A.H., Cullor J.S.;
Title
"Purification, primary structures, and antibacterial activities of beta-defensins, a new family of antimicrobial peptides from bovine neutrophils."; J. Biol. Chem. 268:6641-6648.
Year Source
1993 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)N[C@@]([H])(CS)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)NCC(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(CS)C(=O)N[C@@]([H])(C(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CS)C(=O)N1[C@@]([H])(CCC1)C(=O)NCC(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)NCC(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)N[C@@]([H])(CS)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)NCC(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CS)C(=O)N[C@@]([H])(CS)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CO)C(=O)N[C@@H](Cc1c[nH]c2c1cccc2)C(=O)O


InChI=1S/C197H325N71O48S6/c1-18-98(11)147(179(305)231-85-142(278)257-151(102(15)270)184(310)254-131(91-320)172(298)245-121(75-105-43-24-22-25-44-105)155(281)232-86-143(279)266-72-40-59-135(266)176(302)240-119(57-39-71-227-197(217)218)163(289)261-148(99(12)19-2)181(307)242-113(49-30-31-63-198)159(285)251-129(89-318)173(299)253-128(88-317)170(296)237-114(52-34-66-222-192(207)208)158(284)250-127(87-269)169(295)249-126(189(315)316)77-107-81-228-110-48-29-28-47-109(107)110)260-164(290)120(61-62-137(199)273)239-156(282)116(54-36-68-224-194(211)212)244-185(311)152(103(16)271)264-161(287)112(51-33-65-221-191(205)206)234-140(276)84-230-175(301)134-58-41-73-267(134)187(313)133(93-322)256-160(286)117(55-37-69-225-195(213)214)243-182(308)150(101(14)21-4)263-177(303)136-60-42-74-268(136)188(314)146(97(9)10)259-174(300)132(92-321)252-165(291)122(76-106-45-26-23-27-46-106)235-141(277)83-229-154(280)111(50-32-64-220-190(203)204)236-166(292)125(80-139(201)275)248-183(309)149(100(13)20-3)262-162(288)118(56-38-70-226-196(215)216)238-171(297)130(90-319)255-186(312)153(104(17)272)265-180(306)145(96(7)8)258-168(294)123(78-108-82-219-94-233-108)246-167(293)124(79-138(200)274)247-157(283)115(53-35-67-223-193(209)210)241-178(304)144(202)95(5)6/h22-29,43-48,81-82,94-104,111-136,144-153,228,269-272,317-322H,18-21,30-42,49-80,83-93,198,202H2,1-17H3,(H2,199,273)(H2,200,274)(H2,201,275)(H,219,233)(H,229,280)(H,230,301)(H,231,305)(H,232,281)(H,234,276)(H,235,277)(H,236,292)(H,237,296)(H,238,297)(H,239,282)(H,240,302)(H,241,304)(H,242,307)(H,243,308)(H,244,311)(H,245,298)(H,246,293)(H,247,283)(H,248,309)(H,249,295)(H,250,284)(H,251,285)(H,252,291)(H,253,299)(H,254,310)(H,255,312)(H,256,286)(H,257,278)(H,258,294)(H,259,300)(H,260,290)(H,261,289)(H,262,288)(H,263,303)(H,264,287)(H,265,306)(H,315,316)(H4,203,204,220)(H4,205,206,221)(H4,207,208,222)(H4,209,210,223)(H4,211,212,224)(H4,213,214,225)(H4,215,216,226)(H4,217,218,227)/t98-,99-,100-,101-,102+,103+,104+,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,144-,145-,146-,147-,148-,149-,150-,151-,152-,153-/m0/s1


InChIKey : FZPUBINXNAFFMV-FAYKYCHASA-N


From Bos taurus (Bovine).
DISULFID: 7-36; 14-29; 19-37


Database reference:
SWISS-PROT BD02_BOVIN