BIOPEP-UWM: Report

ID 5482
Name beta-defensin 11
sequence
GPLSCRRNGGVCIPIRCPGPMRQIGTCFGRPVKCCRSW
Function:
Has bactericidal activity. Active against E.coli ML35 and S.aureus 502A.
 
Number of residues
38
Activity code
ab
Activity :
antibacterial
Chemical mass 4163.0018 Monoisotopic mass 4160.0283
EC50 :
0.00 µM


Bibliographic data:
Authors
Selsted M.E., Tang Y.-Q., Morris W.L., McGuire P.A., Novotny M.J., Smith W., Henschen A.H., Cullor J.S.;
Title
"Purification, primary structures, and antibacterial activities of beta-defensins, a new family of antimicrobial peptides from bovine neutrophils."; J. Biol. Chem. 268:6641-6648.
Year Source
1993 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: NCC(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CS)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CC(=O)N)C(=O)NCC(=O)NCC(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CS)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CS)C(=O)N1[C@@]([H])(CCC1)C(=O)NCC(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CCSC)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)NCC(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)N[C@@]([H])(CS)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)NCC(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CS)C(=O)N[C@@]([H])(CS)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CO)C(=O)N[C@@H](Cc1c[nH]c2c1cccc2)C(=O)O


InChI=1S/C175H290N60O44S7/c1-15-90(10)134(161(270)202-77-129(244)226-137(93(13)238)165(274)223-116(84-283)153(262)213-108(69-94-36-19-18-20-37-94)138(247)201-76-127(242)204-106(46-30-61-197-175(190)191)166(275)234-65-34-50-122(234)159(268)227-133(89(8)9)163(272)211-98(40-23-24-55-176)144(253)219-115(83-282)154(263)221-114(82-281)152(261)208-102(44-28-59-195-173(186)187)143(252)217-111(79-236)149(258)216-110(169(278)279)70-95-73-198-97-39-22-21-38-96(95)97)228-147(256)104(52-53-124(178)239)209-141(250)99(41-25-56-192-170(180)181)206-146(255)105(54-67-286-14)210-157(266)121-49-32-63-232(121)131(246)78-203-156(265)119-47-33-64-233(119)167(276)118(86-285)224-145(254)103(45-29-60-196-174(188)189)212-164(273)135(91(11)16-2)229-160(269)123-51-35-66-235(123)168(277)136(92(12)17-3)230-155(264)117(85-284)222-162(271)132(88(6)7)225-128(243)75-199-126(241)74-200-139(248)109(71-125(179)240)214-142(251)101(43-27-58-194-172(184)185)205-140(249)100(42-26-57-193-171(182)183)207-151(260)113(81-280)220-150(259)112(80-237)218-148(257)107(68-87(4)5)215-158(267)120-48-31-62-231(120)130(245)72-177/h18-22,36-39,73,87-93,98-123,132-137,198,236-238,280-285H,15-17,23-35,40-72,74-86,176-177H2,1-14H3,(H2,178,239)(H2,179,240)(H,199,241)(H,200,248)(H,201,247)(H,202,270)(H,203,265)(H,204,242)(H,205,249)(H,206,255)(H,207,260)(H,208,261)(H,209,250)(H,210,266)(H,211,272)(H,212,273)(H,213,262)(H,214,251)(H,215,267)(H,216,258)(H,217,252)(H,218,257)(H,219,253)(H,220,259)(H,221,263)(H,222,271)(H,223,274)(H,224,254)(H,225,243)(H,226,244)(H,227,268)(H,228,256)(H,229,269)(H,230,264)(H,278,279)(H4,180,181,192)(H4,182,183,193)(H4,184,185,194)(H4,186,187,195)(H4,188,189,196)(H4,190,191,197)/t90-,91-,92-,93+,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,132-,133-,134-,135-,136-,137-/m0/s1


InChIKey :ZNLRDCFKXBIYOV-FUVKTXINSA-N

From Bos taurus (Bovine).
Disulfid: 5-34; 12-27; 17-35


Database reference:
SWISS-PROT BD11_BOVIN