BIOPEP-UWM: Report

ID 5483
Name beta-defensin 12
sequence
GPLSCGRNGGVCIPIRCPVPMRQIGTCFGRPVKCCRSW
Function:
Has bactericidal activity. Active against E.coli ML35 and S.aureus 502A.
 
Number of residues
38
Activity code
ab
Activity :
antibacterial
Chemical mass 4105.9473 Monoisotopic mass 4102.9956
EC50 :
0.00 µM


Bibliographic data:
Authors
Selsted M.E., Tang Y.-Q., Morris W.L., McGuire P.A., Novotny M.J., Smith W., Henschen A.H., Cullor J.S.;
Title
"Purification, primary structures, and antibacterial activities of beta-defensins, a new family of antimicrobial peptides from bovine neutrophils."; J. Biol. Chem. 268:6641-6648.
Year Source
1993 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides

SMILES: NCC(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CS)C(=O)NCC(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CC(=O)N)C(=O)NCC(=O)NCC(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CS)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CS)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(C(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CCSC)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)NCC(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)N[C@@]([H])(CS)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)NCC(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CS)C(=O)N[C@@]([H])(CS)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CO)C(=O)N[C@@H](Cc1c[nH]c2c1cccc2)C(=O)O


InChI=1S/C174H287N57O44S7/c1-17-90(12)134(160(265)199-77-129(241)221-137(93(15)234)164(269)218-115(83-279)152(257)208-107(68-94-37-21-20-22-38-94)138(243)197-76-127(239)201-105(46-31-60-193-174(187)188)165(270)228-62-33-49-120(228)157(262)222-132(88(8)9)162(267)206-99(41-25-26-55-175)144(249)215-114(82-278)153(258)216-113(81-277)151(256)203-101(44-29-58-191-172(183)184)143(248)212-110(78-232)149(254)211-109(169(274)275)69-95-72-194-97-40-24-23-39-96(95)97)224-147(252)103(52-53-123(177)235)204-142(247)100(43-28-57-190-171(181)182)202-146(251)104(54-66-282-16)205-156(261)119-48-35-64-230(119)167(272)133(89(10)11)223-158(263)121-50-34-63-229(121)166(271)117(85-281)219-145(250)102(45-30-59-192-173(185)186)207-163(268)135(91(13)18-2)225-159(264)122-51-36-65-231(122)168(273)136(92(14)19-3)226-154(259)116(84-280)217-161(266)131(87(6)7)220-128(240)74-195-125(237)73-196-139(244)108(70-124(178)236)209-141(246)98(42-27-56-189-170(179)180)200-126(238)75-198-140(245)112(80-276)214-150(255)111(79-233)213-148(253)106(67-86(4)5)210-155(260)118-47-32-61-227(118)130(242)71-176/h20-24,37-40,72,86-93,98-122,131-137,194,232-234,276-281H,17-19,25-36,41-71,73-85,175-176H2,1-16H3,(H2,177,235)(H2,178,236)(H,195,237)(H,196,244)(H,197,243)(H,198,245)(H,199,265)(H,200,238)(H,201,239)(H,202,251)(H,203,256)(H,204,247)(H,205,261)(H,206,267)(H,207,268)(H,208,257)(H,209,246)(H,210,260)(H,211,254)(H,212,248)(H,213,253)(H,214,255)(H,215,249)(H,216,258)(H,217,266)(H,218,269)(H,219,250)(H,220,240)(H,221,241)(H,222,262)(H,223,263)(H,224,252)(H,225,264)(H,226,259)(H,274,275)(H4,179,180,189)(H4,181,182,190)(H4,183,184,191)(H4,185,186,192)(H4,187,188,193)/t90-,91-,92-,93+,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,131-,132-,133-,134-,135-,136-,137-/m0/s1


InChIKey: HMLKXMAXAXYIGB-TUJLLIBRSA-N


From Bos taurus (Bovine).
Disulfid: 5-34; 12-27; 17-35


Database reference:
SWISS-PROT BD12_BOVIN