BIOPEP-UWM: Report
| ID | 7001 |
| Name | synthetic peptide from alpha-gliadin |
| sequence |
| Function: | |||
| Number of residues | 12 |
Activity code | ctox |
| Activity : | celiac toxic |
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| Chemical mass | 1392.4700 | Monoisotopic mass | 1391.6772 | |
| EC50 : | 0.00 µM |
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| Bibliographic data: | |
| Authors | |
| Krupickova S., Tuckova L., Flegelove Z., Michalak M., Walters J. R. F., Whelan A., Harries J., Vencovsky J., Tlaskalova-Hogenova H. | |
| Title | |
| Identification of common epitopes on gliadin, enterocytes, and calreticulin recognised antigliadin antibodies of patients with coeliac disease. Gut, 1999, 44, 168-173 | |
| Year | Source |
| 1999 | Journal |
| Additional information: |
| Coeliac disease is a permanent intolerance to the gluten or storage proteins found in some cereals. According to De Ritis and coworkers, small sequences of amino acids are common to the peptides linked with the toxicity. It has also been suggested that Tyr-containing motif is also associated with toxicity. Coeliac disease has many similarities with autoimmune system. Sera of patients with coeliac contain high concentration of antibodies to gliadin. |
| Database reference: |