BIOPEP-UWM: Report

ID 7414
Name ACE inhibitor
sequence
LRW

Function:
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
 
Number of residues
3
Activity code
ah
Activity :
ACE inhibitor
Chemical mass 473.5671 Monoisotopic mass 473.2743
IC50 :
0.15 µM



Bibliographic data:
Authors
Wu J., Yuan L., Aluko R.
Title
Restriction of the in vitro formation of angiotensin II by leucinyl-arginyl-tryptophan a novel peptide with potent angiotensin I converting inhibitory activity. Biosci. Biotechnol. Biochem., 70(5) 1277-1280, 2006
Year Source
2006 Journal



Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC1=C[N]([H])C2=CC=CC=C12)C(=O)O

InChI=1S/C23H35N7O4/c1-13(2)10-16(24)20(31)29-18(8-5-9-27-23(25)26)21(32)30-19(22(33)34)11-14-12-28-17-7-4-3-6-15(14)17/h3-4,6-7,12-13,16,18-19,28H,5,8-11,24H2,1-2H3,(H,29,31)(H,30,32)(H,33,34)(H4,25,26,27)/t16-,18-,19-/m0/s1

InChIKey=XYUBOFCTGPZFSA-WDSOQIARSA-N


LRW was found within the primary structure of legumin A2 of a garden pea seeds (Pisum sativum) (position:377-379) and legumin A (position: 374-376).

Peptide stimulating activity of osteoblasts according to the BIOPEP-UWM database of bioactive peptides (ID 9878)



Database reference:
AHTPDB: ID 1989

BioPepDB: ID biopep00889

BIOPEP-UWM database of bioactive peptides: ID 9878

EROP-Moscow: ID E23787

FeptideDB: ID 7414

ChemSpider: ID 16572302

MeSH: term Leu-Arg-Trp

PlantPepDB: ID PPepDB_140

PubChem: CID 60206537