BIOPEP-UWM: Report

ID 7483
Name ACE inhibitor (fr. of as1-casein, 1-9)
sequence
RPKHPIKHQ
Function:
Inhibitor of Angiotensin-converting enzyme (EC 3.4.15.1) (MEROPS ID: M02-001)
 
Number of residues
9
Activity code
ah
Activity :
ACE inhibitor
Chemical mass 1140.3379 Monoisotopic mass 1139.6658
IC50 :
13.00 µM


Bibliographic data:
Authors
Saito T., Nakamura T., Kitazawa H., Kawai Y., Itoh T.
Title
Isolation and structural analysis of antihypertensive peptides that exist naturally in Gouda cheese. J. Dairy Sci., 2000, 83, 1434-1440
Year Source
2000 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC2=CN=C[N]2[H])C(=O)N3CCC[C@@H]3C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC4=CN=C[N]4[H])C(=O)N[C@@H](CCC(=O)N)C(=O)O

InChI=1S/C51H85N19O11/c1-3-29(2)41(47(77)64-34(13-5-7-19-53)42(72)66-36(23-30-25-58-27-61-30)44(74)65-35(50(80)81)16-17-40(55)71)68-46(76)39-15-10-22-70(39)49(79)37(24-31-26-59-28-62-31)67-43(73)33(12-4-6-18-52)63-45(75)38-14-9-21-69(38)48(78)32(54)11-8-20-60-51(56)57/h25-29,32-39,41H,3-24,52-54H2,1-2H3,(H2,55,71)(H,58,61)(H,59,62)(H,63,75)(H,64,77)(H,65,74)(H,66,72)(H,67,73)(H,68,76)(H,80,81)(H4,56,57,60)/t29-,32-,33-,34-,35-,36-,37-,38-,39-,41-/m0/s1

InChIKey: LGFGAWNELRGQQH-YIJACBTNSA-N


Hypotensive peptide according to the EROP-Moscow database

Bitter peptide according to the BIOPEP-UWM database of sensory peptides and amino acids (ID 427).


Database reference:
AHTPDB: ID 1704; 2366; 2760; 3617; 3623; 4192; 4379; 4608; 5043; 5685; 6065; 6494

BIOPEP-UWM database of sensory peptides and amino acids: ID 427

ChemSpider: ID 8300040

EROP-Moscow: ID E14717

FeptideDB: ID 7483

MBPDB: peptide RPKHPIKHQ

PepBank: peptide RPKHPIKHQ

PubChem: CID 10124521

SATPdb: ID satpdb24333