BIOPEP-UWM: Report

ID 7493
Name ACE inhibitor (from bovine beta-CN)
sequence
DKIHPF
Function:
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
 
Number of residues
6
Activity code
ah
Activity :
ACE inhibitor
Chemical mass 755.8588 Monoisotopic mass 755.3954
IC50 :
257.00 µM


Bibliographic data:
Authors
Gobbetti M., Ferranti P., Smacchi E., Goffredi F., Addeo F.
Title
Production of angiotensin-I-converting-enzyme-inhibitory peptides in fermented milks started by Lactobacillus delbrueckii subsp. bulgaricus SS1 and Lactococcus lactis subsp. cremoris FT4. Appl. Env. Microbiol., 66, 3898-3904, 2000
Year Source
2000 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides

SMILES: N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@H](CC)C)C(=O)N[C@@H](CC1=C[N]([H])C=N1)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC3=CC=CC=C3)C(=O)O

InChI=1S/C36H53N9O9/c1-3-21(2)30(44-32(49)25(12-7-8-14-37)41-31(48)24(38)18-29(46)47)34(51)42-26(17-23-19-39-20-40-23)35(52)45-15-9-13-28(45)33(50)43-27(36(53)54)16-22-10-5-4-6-11-22/h4-6,10-11,19-21,24-28,30H,3,7-9,12-18,37-38H2,1-2H3,(H,39,40)(H,41,48)(H,42,51)(H,43,50)(H,44,49)(H,46,47)(H,53,54)/t21-,24-,25-,26-,27-,28-,30-/m0/s1

InChIKey=KDBXTZUSBPMDFS-YYNHRMGXSA-N



Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/); ID: M02-001

Peptide found in yoghurt:

Farvin K. H. S., Baron C. P., Nielsen N. S., Jacobsen C., 2010, Antioxidant activity of yoghurt peptides: part 2 – Characterisation of peptide fractions. Food Chem., 123, 1090-1097

IC50 according to:
Van der Ven C., 2002, Biochemical and functional characterisation of casein and whey protein hydrolysates. A study on correlations between biochemical and functional properties using multivariate data analysis. Dissertation


Database reference:
AHTPDB: ID 2490, 3408, 3649, 4291, 4314, 5929, 5957, 6058, 6503

ChemSpider ID17228127

EROP-Moscow: ID E07419

FeptideDB: ID 7493

FermFooDB: ID FMDB1253, FMDB1307, FMDB1598, FMDB1618, FMDB1623,
FMDB1634, FMDB1647, FMDB1695, FMDB1806, FMDB1807

MBPDB: Peptide DKIHPF

PubChem: CID 16068557

SATPdb: ID satpdb22634