BIOPEP-UWM: Report
| ID | 7512 |
| Name | ACE inhibitor from Alaskan pollack skin |
| sequence |
| Function: | |||
| Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001) | |||
| Number of residues | 2 |
Activity code | ah |
| Activity : | ACE inhibitor |
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| Chemical mass | 172.1813 | Monoisotopic mass | 172.0845 | |
| EC50 : | 252.63 µM |
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| Bibliographic data: | |
| Authors | |
| Byun H.-G., Kim S.-K. | |
| Title | |
| Structure and activity of angiotensin I-converting enzyme inhibitory peptides derived from Alaskan pollack skin. Bioch. Mol. Biol., 35, 2, 239-243, 2002 | |
| Year | Source |
| 2002 | Journal |
| Additional information: |
BIOPEP-UWM database of bioactive peptides SMILES: C1C[C@H](N(C1)C(=O)CN)C(=O)O InChI=1S/C7H12N2O3/c8-4-6(10)9-3-1-2-5(9)7(11)12/h5H,1-4,8H2,(H,11,12)/t5-/m0/s1 InChIKey: KZNQNBZMBZJQJO-YFKPBYRVSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/); ID: M02-001 Another value of peptide IC50 (EC50) = 450 uM Meisel H., Walsh D. J., Murray B., FitzGerald R. J., 2006. ACE inhibitory peptides. In: Nutraceultical Proteins and Peptides in Health and Disease. Taylor and Francis Group, Boca Raton, London, New York, 269-315. Another value of peptide IC50 (EC50) = 360 uM Ichimura T., Yamanaka A., Otsuka T., Yamashita E., Maruyama S., 2009, Antihypertensive effect of enzymatic hydrolysate of collagen and Gly-Pro in spontaeously hypertensive rats. Biosci. Biotech. Biochem., 73, 2317-2319 Reveals activity in vivo in spontaneously hypertensive rats. Ichimura T., Yamanaka A., Otsuka T., Yamashita E., Maruyama S., 2009, Antihypertensive effect of enzymatic hydrolysate of collagen and Gly-Pro in spontaeously hypertensive rats. Biosci. Biotech. Biochem., 73, 2317-2319 Inhibitor of dipeptidyl peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP-UWM database of bioactive peptides (ID 3169); Antithrombotic peptide according to the BIOPEP-UWM database of bioactive peptides (ID 3283); Inhibitor of prolyl endopeptidase (EC 3.4.21.26) (MEROPS ID: S09.001) according to the BIOPEP-UWM database of bioactive peptides (ID 3461) Regulator of the stomach mucosal membrane activity according to the BIOPEP-UWM database of bioactive peptides (ID 2753) Bitter peptide according to the BIOPEP-UWM database of sensory peptides and amino acids, the ChEMBL database; the EROP-Moscow database (ID E03695), the PubChem database |
| Database reference: |
| AHTPDB: ID 1391; 1392; 1420; 3413; 3489; 3614; 3795; 3840; 3930; 4434; 4501; 4694; 5151; 5426; 5642; 5677; 6111; 6163; 6522 BindingDB: ID 50169189 BioCyc: ID CPD-10814 BioPepDB: ID biopep00379 BIOPEP-UWM database of bioactive peptides ID: 2753; 3169; 3283; 3461 BIOPEP-UWM database of sensory peptides and amino acids: ID 17 BRENDA: Ligand Gly-Pro ChEBI: ID 70744 ChEMBL: ID CHEMBL80548 ChemSpider: ID 2282246 EROP-Moscow: ID E03695; E09223 FDA SRS: ID BJZ69WB3VD J-GLOBAL: ID 200907097129168220 MBPDB: Peptide GP Metabolights: ID MTBLC70744 Nikkaji: ID J150.128C PubChem: ID 3013625 Rhea: ID 73779 SATPdb: ID satpdb20549 SureChEMBL: ID SCHEMBL155067 ZINC: ID ZINC01637972 |