BIOPEP-UWM: Report

ID 7544
Name ACE inhibitor
sequence
IW
Function:
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
 
Number of residues
2
Activity code
ah
Activity :
ACE inhibitor
Chemical mass 317.3819 Monoisotopic mass 317.1734
IC50 :
4.70 µM


Bibliographic data:
Authors
Ono S., Hosokawa M., Miyashita K., Takahashi K.
Title
Isolation of peptides with angiotensin I-converting enzyme inhibitory effect derived from hydrolysate of upstream chum salmon muscle. J. Food Sci., 68, 1611-1614, 2003
Year Source
2003 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: CC[C@H](C)[C@H](N)C(=O)N[C@@H](CC1=CNC2=CC=CC=C12)C(O)=O

InChI=1S/C17H23N3O3/c1-3-10(2)15(18)16(21)20-14(17(22)23)8-11-9-19-13-7-5-4-6-12(11)13/h4-7,9-10,14-15,19H,3,8,18H2,1-2H3,(H,20,21)(H,22,23)/t10-,14-,15-/m0/s1

InChIKey: BVRPESWOSNFUCJ-LKTVYLICSA-N


Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/); ID: M02-001

Another value of peptide IC50(EC50)=2.00 uM

Loponen J., 2004, Angiotensin converting enzyme inhibitory peptides in Finnish cereals: a database survey. Agric. Food Sci., 13, 39-45.


Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to BIOPEP-UWM database of bioactive peptides (ID 8807)
Inhibitor of Xanthine oxidase (EC 1.17.3.2) according to EROP-Moscow database
Neuropeptide BNC210 according to ChemSpider database; EROP-Moscow database; Wikipedia



Bitter peptide according to BIOPEP-UWM database of sensory peptides and amino acids; ChEMBL database


Database reference:
AHTPDB: ID 1074; 1085; 1444; 1460; 1468; 1859; 2028; 2214; 2779; 2788; 2847; 2882; 3343; 3503; 3567; 3780; 3863; 3961; 4227; 4237; 4255; 4451; 4486; 4649; 4958; 4959; 5155; 6160; 6264; 6272; 6531; 6880

BindingDB: ID 50407421

BioPepDB: ID biopep00616

BIOPEP-UWM database of bioactive peptides: ID 8807

BIOPEP-UWM database of sensory peptides and amino acids: ID 346

BRENDA: Ligand L-Ile-L-Trp

ChEBI: ID 74080

ChEMBL: ID CHEMBL56923

ChemSpider: ID 5382052

EROP-Moscow: ID E01434

J-GLOBAL: ID 200907081268045678

Metabolights: ID MTBLC74080

Nikkaji: ID J587.917E

OLSVis: ID CHEBI:74080

PubChem: ID 7019084

SATPdb: ID satpdb20183

SureChEMBL: ID SCHEMBL3512696

ZINC: ID ZINC02556614