BIOPEP-UWM: Report

ID 7549
Name ACE inhibitor
sequence
LKP
Function:
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
 
Number of residues
3
Activity code
ah
Activity :
ACE inhibitor
Chemical mass 356.4591 Monoisotopic mass 356.2416
EC50 :
0.32 µM


Bibliographic data:
Authors
Fujita H., Yokoyama K., Yoshikawa M.
Title
Classification of antihypertensive activity of angiotensin I-converting enzyme inhibitory peptides derived from food proteins. J. Food Sci., 65, 564-569, 2000
Year Source
2000 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides

SMILES: [H][C@](N)(CC(C)C)C(=O)N[C@@]([H])(CCCCN)C(=O)N1CCC[C@@]1([H])C(O)=O

InChI=1S/C17H32N4O4/c1-11(2)10-12(19)15(22)20-13(6-3-4-8-18)16(23)21-9-5-7-14(21)17(24)25/h11-14H,3-10,18-19H2,1-2H3,(H,20,22)(H,24,25)/t12-,13-,14-/m0/s1

InChIKey: RTIRBWJPYJYTLO-IHRRRGAJSA-N

Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/); ID: M02-001

Peptide released from myosin by simulated gastric juice.

Terashima M., Baba T., Ikemoto N., Katayama M., Morimoto T., Matsumura S., 2010, Novel angiotensin-converting enzyme (ACE) inhibitory peptides derived from boneless chicken leg meat. J. Agric. Food Chem., 58, 7432-7436

Peptide obtained also from egg white protein hydrolysate.

Huang W.-Y., Majumder K., Wu J., 2010, Oxygen radical absorbance capacity of peptides from egg white protein ovotransferrin and their interactions with phytochemicals. Food Chem., 123, 635-641

Peptide reduced blood pressure in adult male SHRs.

Majumder K., Chakrabarti S., Morton J.S., Panahi S., Kaufman S., Davidge S.T., Wu J., 2015, Egg-derived ACE-inhibitory peptides IQW and LKP reduce blood pressure in spontaneously hypertensive rats. Food Chem.,13, 50-60


Antioxidative peptide according to the BIOPEP-UWM database of bioactive peptides (ID 8216)


Database reference:
AHTPDB: ID 1073, 1521, 1528, 1611, 1660, 1838, 1953, 1969, 1972, 2001, 2002, 2020, 2025, 2216, 2597, 2861, 2892, 2945, 2952, 3011, 3758, 3766, 3770, 3979, 4203, 4222, 4976, 4979, 5059, 5513, 5561, 6535

BindingDB: ID 50348861

BIOPEP-UWM: ID 8216

BRENDA: Ligand Leu-Lys-Pro

ChEMBL: ID CHEMBL1807676

ChemSpider: ID 8648888

EROP-Moscow: ID E01438

J-GLOBAL: ID 200907022084757598

Nikkaji: ID J1.356.196F

PubChem: CID 10473477

SATPdb: ID satpdb17881

SureChEMBL: ID SCHEMBL7757715

ZINC: ID ZINC000038930594