BIOPEP-UWM: Report

ID 7580
Name ACE inhibitor
sequence
RW
Function:
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02.001)
 
Number of residues
2
Activity code
ah
Activity :
ACE inhibitor
Chemical mass 360.4099 Monoisotopic mass 360.1905
EC50 :
16.00 µM


Bibliographic data:
Authors
Cheung H.-S., Wang F.-L., Ondetti M. A., Sabo E. F., Cushman D. W.
Title
Binding of peptide substrates and inhibitors of angiotensin-converting enzyme. J. Biol. Chem., 255, 401-407, 1980
Year Source
1980 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC1=C[N]([H])C2=CC=CC=C12)C(=O)O

InChI=1S/C17H24N6O3/c18-12(5-3-7-21-17(19)20)15(24)23-14(16(25)26)8-10-9-22-13-6-2-1-4-11(10)13/h1-2,4,6,9,12,14,22H,3,5,7-8,18H2,(H,23,24)(H,25,26)(H4,19,20,21)/t12-,14-/m0/s1

InChIKey=QADCERNTBWTXFV-JSGCOSHPSA-N

Antioxidative peptide according to the BIOPEP-UWM database of bioactive peptides (ID 8214)
Inhibitor of Dipeptidyl peptidase III (EC 3.4.14.4) (MEROPS ID: M49.001) according to the BIOPEP-UWM database of bioactive peptides (ID 9477); the BRENDA database
Inhibitor of Dipeptidyl peptidase IV (DPP IV) (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP-UWM database of bioactive peptides (ID: 8890)
Antiviral peptide according to the AVPdb database
Inhibitor of Xanthine oxidase (EC 1.17.3.2) according to the EROP-Moscow database


Information concerning angiotensin-converting enzyme is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/); ID: M02-001)


Database reference:
AHTPDB: ID 1221, 1497, 1513, 2058, 2848, 3535, 3783, 4448, 4489, 4658, 6566

AVPdb: ID AVP1529

BindingDB: ID 50407441

BioPepDB: ID biopep01230

BIOPEP-UWM database of bioactive peptides: ID 8214; 8890, 9477

BRENDA: Ligand Arg-Trp

ChEBI: ID 73821

ChEMBL: ID CHEMBL91160

ChemSpider: ID 5373233

EPA CompTox: ID DTXSID00426569

EPA DSSTox: ID DTXSID00426569

EROP-Moscow: ID E10401

J-GLOBAL: ID 200907005445591086

Metabolights: ID MTBLC73821

Nikkaji: ID J36.199B

PubChem: CID 7009653

SATPdb: ID satpdb26916

SureChEMBL: ID SCHEMBL5326395

ZINC: ID ZINC2384977